FIGURE 2.

HMGB1⁺ plt‐EVs concentration is associated with COVID‐19 severity and predicts clinical outcomes. The concentration of HMGB1⁺ plt‐EVs correlates with the concentration of C‐reactive protein (CRP; A), of D‐dimer (B), with hypoxia as reflected by the arterial oxygen partial pressure/fractional inspired oxygen (PaO₂/FiO₂, C) and with the concentration of lactate dehydrogenase (LDH, D) while being significantly higher in patients who will develop acute respiratory distress syndrome (ARDS) (E) and who will experience more severe disease, as reflected by the maximum score achieved using the World Health Organization ordinal scale as a surrogate for clinical deterioration (F). Symbols depict individual observations in each subject. Statistical differences were determined as described in the Methods.