FIGURE 3.

Severe acute respiratory syndrome coronavirus 2 virions are present in both megakaryocytes and platelets of COVID‐19 patients. A, H&E staining and CD61 immunohistochemistry of bone marrow of a COVID‐19 patient. B, Transmission electron microscopy of bone marrow of a COVID‐19 patient, identified SARS‐CoV‐2 viruses are circled in red. C, Transmission electron microscopy of platelets from three COVID‐19 patients; dash frame is enlarged area of corresponding image. D, Amplification plots of SARS‐CoV‐2‐specific real‐time quantitative polymerase chain reaction (RT‐qPCR) of Meg01s treated with media control (n = 2) or SARS‐CoV‐2 (n = 3) for 6 h. E, SARS‐CoV‐2‐‐specific RT‐qPCR of Meg01s treated with media control (n = 2) or SARS‐CoV‐2 (n = 3) for 6 h at 37°C. F, Expression of ACE2, CD147, DC‐SIGN, L‐SIGN, CLEC10A, CLEC4G, and ASGR1 mRNA in platelets from COVID‐19 patients and matched controls as determined by RNASeq. G, Surface expression of CD147 as determined by flow cytometry of CD34±derived megakaryocytes. Data are expressed as mean ± standard error of the mean, ****P < .001