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. 2021 Nov 30;16:7813–7830. doi: 10.2147/IJN.S335757

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© 2021 Lu et al.

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Micro-PET/CT imaging and quantitative analysis of [¹⁸F]NaF. (A) Axial, coronal, sagittal, and volume rendering view of [¹⁸F]NaF tracer activity at the 1, 3, 7, and 15 weeks post OVX in OVX-200 μg EVs, OVX-PBS, and Sham groups. (B and C) Quantification of [¹⁸F]NaF uptake in distal femur using %ID/cc or SUVmean methods. Data are expressed as mean±SD (*p<0.05, ^#P<0.05 and ^##P<0.01). *Indicate a significant difference between OVX-200 μg EVs and OVX-PBS. ^#Indicate significant differences from Sham and OVX-PBS groups.

Abbreviations: OVX, ovariectomy; PBS, phosphate buffered saline; PET, positron emission tomography; CT, computed tomography; SUV, standardized uptake values.