TABLE 1.
Representative studies reporting thromboembolic/hemorrhagic manifestations of subacute and/or chronic COVID‐19
| Study | Design | Study population | Type of event | Anticoagulation | Time interval between diagnosis and time of event |
|---|---|---|---|---|---|
| Patell et al. 18 | Retrospective observational |
n = 163 F: 52.2% Obesity: NR |
VTE 2.5% 1 PE 1 ICT 1 thrombosed AV fistula 1 ischemic stroke Hemorrhagic events: 3.7% 2 MB 4 CRNMB |
No |
Median duration to thrombotic event post discharge 23 days (IQR: 12–33) Median duration to event post discharge: 27 days (IQR 16–31 days) |
| Roberts et al. 19 | Retrospective observational |
n = 1877 F: NR Obesity: NR |
VTE n = 9 (11%) 2 proximal DVT 7 PE |
No | Median duration to event post discharge 8 days (IQR, 3–33 days) |
| Engelen et al. 20 | Prospective cohort study Systematic post‐discharge screening |
n = 102 F: NR Obesity: NR |
0 symptomatic events 1 asymptomatic VTE |
8% on prophylactic LMWH | Outpatient follow‐up screening at 6 weeks post discharge |
| Bourguignon et al. 21 | Retrospective cohort study |
n = 140 Discharged from medical ward F: 46% Obesity: NR n = 35 discharged from rehab ward F: 63% Obesity: NR |
0.71% n = 1 PE 0% |
10% on anticoagulation at discharge 29% on anticoagulation at discharge |
Event at 9 days post discharge |
| Huang et al. 22 | Cohort study with systematic screening |
n = 2469 F: 48% n = 390 F: NR Obesity: NR |
Three ischemic strokes one PE (only events requiring re‐admission reported) No asymptomatic VTE in screening |
NR NR |
NR NA |
| Giannis et al. 23 | Prospective registry |
n = 4906 F: 46% Obesity: 18.9% |
n = 76 (1.55%) VTE DVT 44 PE 42 Splanchnic VT 2 n = 84 (1.71%) ATE stroke 22 MI 24 MLE 26 S. embolism 16 n = 85 (1.73%) MB |
12.7% on thromboprophylaxis n = 62 (1.3%) enoxaparin n = 3 (0.06%) UFH n = 180 (3.7%) apixaban n = 336 (6.9%) rivaroxaban |
Outcomes at 90 days post discharge |
| Spyropoulos et al. 24 | Case series |
n = 4 M: 100% Obesity: 0% |
Two large‐vessel ischemic strokes one acute ischemic limb (emboli from aortic thrombosis) one AL STEMI |
No | Median time to event post diagnosis: 72 days |
Abbreviations: AL STEMI, anteriolateral ST‐elevation myocardial infarction; ATE, arterial thromboembolism; CRNMB, clinically relevant non‐major bleed; DVT, deep vein thrombosis; ICT, intracardiac thrombus; MB, major bleeding; MLE, major limb event; PE, pulmonary embolism; S. embolism, systemic embolism; UFH, unfractionated heparin; VTE, venous thromboembolism.