Table 1.
Patient | Age | Sex | Duration of SLE* (years) | Immunosuppressive treatments | Initial vaccine series | Booster vaccine type | Days from initial to booster vaccine | Anti-RBD pan-Ig¶ by Roche Elecys (U/mL) | Anti-RBD-IgG¶ by Abbott assay (AU/mL) | sVNT‡ (% inhibition) | IFN-γ ELISpot§ (SFC/106 PBMCs) |
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Prebooster | Postbooster† | Prebooster | Postbooster† | Prebooster (%) | Postbooster (%)† | Postbooster† | ||||||||
1 | 27 | Female | 5 | Azathioprine 100 mg/day Ciclosporin 100 mg/day Prednisolone 10 mg/day |
CoronaVac | Pfizer | 113 | 342 | 24 416 | 275 | 36 182 | 16.74 | 99.70 | 62 |
2 | 19 | Female | 0 | Prednisolone 10 mg/day Hydroxychloroquine 1000 mg/week |
CoronaVac | Pfizer | 94 | 83 | 15 076 | 332 | 25 719 | 27.94 | 98.98 | 228 |
3 | 50 | Female | 24 | Mycophenolate mofetil 1000 mg/day Prednisolone 10 mg/day Hydroxychloroquine 400 mg/week |
CoronaVac | Pfizer | 83 | 50 | 18 213 | 96 | 26 152 | <1 | 99.42 | 88 |
4 | 50 | Female | 13 | Prednisolone 5 mg/day Hydroxychloroquine 1400 mg/week |
CoronaVac | ChAdOx1 | 86 | 21 | 6098 | 170 | 9756 | 4.79 | 99.19 | 414 |
5 | 41 | Female | 24 | Prednisolone 5 mg/day Hydroxychloroquine 1400 mg/week |
CoronaVac | Pfizer | 92 | 32 | 21 759 | 104 | 34 784 | <1 | 99.48 | 624 |
6 | 23 | Female | 17 | Prednisolone 5 mg/day | CoronaVac | Pfizer | 72 | 97 | 15 087 | 300 | 25 955 | 12.56 | 94.95 | 646 |
7 | 21 | Female | 4 | Azathioprine 100 mg/week Prednisolone 2.5 mg/day Hydroxychloroquine 1000 mg/week |
CoronaVac | Pfizer | 97 | 434 | 85 024 | 916 | 80 051 | 74.93 | 99.48 | 1200 |
8 | 29 | Female | 8 | Tacrolimus 5 mg/day Prednisolone 2.5 mg/day Hydroxychloroquine 400 mg/week |
CoronaVac | Pfizer | 92 | NA | 71 508 | NA | 96 572 | NA | 99.64 | NA |
*Systemic lupus erythematosus.
†14 days after booster vaccination.
‡SARS-CoV-2 Surrogate Virus Neutralization Test (NeutraLISA, Euroimmun, Lübeck, Germany) reported as % neutralisation.
§IFN-γ ELISpot reported as spot-forming cell per million peripheral blood mononuclear cells.
¶Anti-SARS-CoV-2 spike receptor binding domain (RBD) IgG antibody concentrations reported as.U/mL or AU/mL.
ELISpot, enzyme-linked immunosorbent spot; IFN-γ, interferon gamma; NA, not applicable; SFC, spot-forming cell; SLE, systemic lupus erythematosus.