Fig. 1.

Muscle-specific expression of mutant LamC reduced larval motility. (A) LamC protein domains are diagrammed, and amino acid substitutions used in this study are labeled. (B) Ribbon diagrams of the Ig-fold domain of human lamin A/C (PBD: 1IVT) displaying the positions of the amino acid substitutions used in this study. (C) Larval crawling velocity for each genotype tested is plotted. Larval velocity was measured using 2-min video clips and processed with ImageJ. One-way ANOVA analysis was used to determine statistical significance among the average values with the wild-type (wt) as the control.