Figure EV5. Bone phenotype of osteoclast‐specific Tet2‐ and Tet3‐deficient mice.

• A
  μCT analysis of the femurs from 10‐week‐old control, Tet2_Rank ^–/– , Tet3_Rank ^–/– , Tet2_Rank ^–/–; Tet3a_Rank ^+/– , Tet2_Rank ^+/–; Tet3a_Rank ^–/– and Tet2_Rank ^–/–; Tet3a_Rank ^–/– male mice (longitudinal view of the metaphyseal region). Scale, 0.5 mm.
• B, C
  Histological analysis of the proximal tibias of 10‐week‐old control, Tet2_Rank ^–/– , Tet3_Rank ^–/– , Tet2_Rank ^–/–; Tet3a_Rank ^+/– , Tet2_Rank ^+/–; Tet3a_Rank ^–/– and Tet2_Rank ^–/–; Tet3a_Rank ^–/– male mice (C, toluidine blue staining; D, calcein labeling). Scale, 100 μm.
• D
  Osteoblastic parameters of osteoclast‐specific Tet2‐ and Tet3‐deficient mice. Bone morphometric analysis of 10‐week‐old control (n = 10), Tet2_Rank ^–/– (n = 5), Tet3_Rank ^–/– (n = 6), Tet2_Rank ^–/–; Tet3a_Rank ^+/– (n = 6), Tet2_Rank ^+/–; Tet3a_Rank ^–/– (n = 6), and Tet2_Rank ^–/–; Tet3a_Rank ^–/– (n = 4) male mice was performed. Data denote mean ± s.e.m. **P < 0.01; NS, not significant (ANOVA).