Table 3.

Parameter estimates from hierarchical linear regression models of PiB status, IL-6 and their interaction product as predictors of change in global and regional Aβ deposition from baseline to follow-up.

Region	Baseline PiB Status			Interleukin-6			PiB Status X Interleukin-6
	Estimate	Standard Error	p-value	Estimate	Standard Error	p-value	Estimate	Standard Error	t-value	p-value	R2 change
Global PiB SUVR	0.099	0.049	0.049	0.057	0.094	0.544	0.49	0.184	2.65	0.011	0.095
Frontal Cortex	0.190	0.062	0.003	0.006	0.119	0.958	0.341	0.243	1.40	0.167	0.026
Anterior Cingulate Gyrus	0.197	0.073	0.010	0.245	0.140	0.086	0.732	0.275	2.67	0.010	0.090
Precuneus Cortex	0.043	0.053	0.417	0.117	0.101	0.254	0.48	0.201	2.39	0.02	0.077
Parietal Cortex	0.047	0.054	0.379	0.059	0.102	0.569	0.61	0.17	3.12	0.003	0.130
Anterior Ventral Striatum	0.069	0.044	0.123	−0.11	0.084	0.18	0.12	0.17	0.69	0.495	0.007
Lateral Temporal Cortex	0.09	0.048	0.073	−0.022	0.091	0.81	0.49	0.18	2.75	0.008	0.101

Data from moderation models adjusting for age, sex, years of education, duration (weeks) from blood draw to imaging, history of heart disease, iabetes, current anti-hypertensive medication use, duration between consecutive PiB-PET scans, depressive symptoms, APOE ε4, and white matter hyperintensities. Abbreviations: PiB = Pittsburgh compound-B; SUVR = standardized uptake value ratio