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. 2021 Oct 14;22(12):e52124. doi: 10.15252/embr.202052124

Figure 5. LncRNA CRNDE induces CDDP resistance in vivo .

Figure 5

3 × 105 MFC cells were subcutaneously injected into nude mice. Ten days after injection, BMDMs‐exo, M2‐exo, M2‐si‐control‐exo, or M2‐si‐CRNDE‐exo (10 µg) was injected into the center of the homograft tumors of mice (n = 7 each group), followed by intraperitoneal injection of CDDP (10 mg/kg). Six days after CDDP treatment, all mice were sacrificed and the homograft tumors were collected.
  • A
    Growth curves of MFC subcutaneous homograft tumors (The homograft tumor sizes were recorded from the day of CDDP treatment). *P < 0.05, **P < 0.01 vs. BMDMs‐exo; #P < 0.05, ##P < 0.01 vs. M2‐si‐control‐exo.
  • B, C
    The homograft tumors (B) photos and (C) weight of each mouse on day 6 after CDDP injection. **P < 0.01.
  • D
    LncRNA CRNDE expression in homograft tumors of mice. **P < 0.01.

Data information: Data are expressed as mean ± SD. (A, C and D): one‐way ANOVA.