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. 2021 Oct 7;22(12):e52964. doi: 10.15252/embr.202152964

Figure EV4. ATFS‐1 and ATF‐7 bind to the same genes involved in innate immunity.

Figure EV4

Innate immunity genes are defined as genes that are upregulated by a 4‐h exposure to PA14. This list was obtained from Fletcher et al (2019b). ATF‐7‐bound genes are genes bound by ATF‐7 after exposure to PA14 from a CHIP‐seq experiment conducted by Fletcher et al (2019b). ATFS‐1‐bound genes are genes bound by ATFS‐1 after mitochondrial stress resulting from RNAi against spg‐7 as determined by a CHIP‐seq experiment conducted by Nargund et al (2015b). ATF‐7 was found to be bound to 345 innate immunity genes after exposure to PA14. ATFS‐1 was found to be bound to 50 innate immunity genes after exposure to mitochondrial stress. Of these 50 genes, 24 were found to be in common with ATF‐7‐bound innate immunity genes. This highly significant overlap (P = 1.72 × 10−29) clearly demonstrates that ATF‐7 and ATFS‐1 can bind to and regulate the same innate immunity genes. See Dataset EV2 for the complete gene lists.

Data information: The P‐value indicates the significance of the difference between the observed number of overlapping genes between the two gene sets and the expected number of overlapping genes if the genes were picked at random.