Table I.
Patient demographics and mean peripheral blood (PB) haematological parameters in SCD and non-SCD subjects.
| SCD subgroups |
|||||
|---|---|---|---|---|---|
| Non-SCD | SCD (all) | Off hydroxycarbamide | On hydroxycarbamide | Chronic transfusions | |
| Subjects (n) | 5 | 19 | 4 | 12 | 3 |
| Gender (male, %) | 2 (40) | 12 (63) | 4 (100) | 6 (50) | 2 (67) |
| Age in years (median) | 22 | 31 | 32 | 29 | 29 |
| WBC count (×109/l) | 6.1 ± 2.3 | 9.1 ± 2.8* | 10.1 ± 2.6 | 9.2 ± 3.1 | 7.5 ± 1.0 |
| Hb (g/l) | 137 ± 16 | 85 ± 12** | 80 ± 90 | 85 ± 9.0 | 97 ± 21 |
| MCV (fl) | 85 ± 10 | 95 ± 11 | 85 ± 11* | 99 ± 9 | 96 ± 7 |
| Platelet count (×109/l) | 295 ± 54 | 353 ± 105 | 314 ± 24 | 382 ± 107 | 289 ± 148 |
| ARC (×109/l) | N/A | 334 ± 146 | 317 ± 78 | 338 ± 136 | 341 ± 283 |
| ANC (×109/l) | 3.616 ± 1.86 | 5.056 ± 2074 | 5.040 ± 2.592 | 5.18 ± 2.254 | 4.626 ± 0.85 |
| % HbS | N/A | 60.9 ± 27 | 80 ± 18.8 | 63.5 ± 23.2 | 27.0 ± 17.8* |
| % HbA | 96.7 ± 3.7 | 28.7 ± 30.1** | 9.5 ± 16.3 | 22.6 ± 22.8 | 59.5 ± 18.4** |
| % HbF | <10 ± 23 | 7.7 ± 5.7** | 4.6 ± 3.0 | 9.5 ± 6.5 | 5.8 ± 3.5 |
ANC, absolute neutrophil count; ARC, absolute reticulocyte count; BM, bone marrow; CT, chronic transfusions; Hb, haemoglobin; HbA, adult haemoglobin; HbF, fetal haemoglobin; HbS, sickle haemoglobin; MCV, mean corpuscular volume; SCD, sickle cell disease; WBC, white blood cell count.
*
P < 0·05,
**
P < 0·01.