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. 2021 Nov 22;12:760381. doi: 10.3389/fimmu.2021.760381

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Copyright © 2021 Xu, Yu, Liu, Wu, Zhang, Cai, Hong, Liu, Tang and Dai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between pathogenic genes and specific cell types. (A) Heatmap representing the AS causal genes expression levels in the specific cell type. The scale bar displays fold change values; Fold change value “0” is given for genes which are not DE, statistical significance was taken at P values of less than 0.05 (P < 0.05). and a fold-change criterion (FC>1.2); (B) Violin-box plots for NFKB expression level by cell type, compared to respective controls. The results for AS are shown in red, and those for NC are in green; ***p < 0.001. (C) Violin plots comparing the expression of selected genes (TNF, NFKB, JUN, JUNB, FOS) in CD8+T cells across AS and NC. The results for AS are shown in red, and those for NC are shown in green.