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. 2021 Dec 1;14:6397–6407. doi: 10.2147/JIR.S339133

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© 2021 Sun et al.

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CircFoxo3 reduces HMGB1 expression by inhibiting KAT7. (A) The expression of KAT7 was measured by qPCR in H9c2 cells treated with circFoxo3 overexpressing vectors. (B–D) The H9c2 cells were treated with KAT7 shRNA. (B) The expression of HMGB1 was measured by qPCR.²⁵ The enrichment of H3K14ac on HMGB1 promoter was detected by ChIP assays. (D) The enrichment of RNA poly II on HMGB1 promoter was analyzed by ChIP assays. (E–H) The H9c2 cells were treated circFoxo3 overexpressing vectors, or co-treated with circFoxo3 overexpressing vectors and KAT7 overexpressing vectors. (E) The expression of HMGB1 was measured by qPCR. (F–H) The enrichment of KAT7, H3K14ac, and RNA poly II was measured by ChIP assays. **p < 0.01.