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. 2021 Dec 1;14:6397–6407. doi: 10.2147/JIR.S339133

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© 2021 Sun et al.

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CircFoxo3 attenuates OGD-induced cardiomyocyte injury and autophagy by targeting KAT7/HMGB1 axis in vitro. (A–G) H9c2 cells were treated with OGD along with transfection of circFoxo3 overexpressing vectors, or co-treated with circFoxo3 overexpressing vectors and KAT7 or HMGB1 overexpressing vectors. (A) Cell viability was determined by CCK-8 assay. (B) Cell apoptosis was determined by flow cytometry. (C and D) The levels of IL-6 and IL-10 in culture medium were checked by ELISA assay. (E–G) The expression of Beclin-1, p62, and LC3 was detected by Western blot analysis. (H) A diagram model of this study was shown. **p < 0.01.