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. 2021 Dec 5;21:331. doi: 10.1186/s12866-021-02394-w

Table.3.

Agreements within and between susceptibility assays of Nocardia spp. isolates with TMP-SMX

Agreement aBroth Microdilution Method Disk Diffusion
Gold Standard Resazurin OD
± 1 ± 2 ± 1 ± 2 ± 1 ± 2
Essential
 Intra-reading 82.0 97.0 73.1 88.5 81.8 93.9 dn.a.
bInter-reading 71.7 89.8 75.0 88.6 dn.a.
  b,cPearson’s r 0.50 0.42 0.36 0.44 dn.a.
  (95% CI) (0.36–0.62) (0.26–0.55) (0.20–0.45) (0.30–0.57)
Categorical
 Intra-reading 95.5 88.5 86.2 86.2 99.2 97.0 100.0
bInter-reading 81.1 91.3 91.7 93.9 97.7
  bVery Major Errors 0.0 0.0 8.33 6.06 2.27
  bMajor Errors 18.9 8.66 0.0 0.0 0.0

aBMD method concordant results considering ±1 or ± 2 two-fold dilutions

bCompared with the Gold Standard BMD method

cP < 0.0001 for all comparisons

dNot applicable