Fig. 4.

Evaluation of CSS performance in independent datasets and construction of a CSS-based nomogram. A Comparisons of clinical features between CSS-low and CSS-high subgroups. B–E Kaplan–Meier curves for patients with high and low CCS in validation I(B), II(C), III(D), IV(E) cohorts. F Meta-analysis. G Representative images (left) and score comparison (right) of IHC staining for LYPD3 in adjacent non-tumor tissues and LUAD tissues. H Survival analysis comparing low and high expression levels of LYPD3 in the Kaplan–Meier plotter database. I Construction of a nomogram combining the CCS and clinical features for prediction of OS. J Calibration analysis indicated a high accuracy of OS prediction. K AUC plotted for different durations of OS for nomogram-based signature, CSS, Age, T stage, N stage and TNM stage in LUAD patients in TCGA cohort