Fig. 6.

Response and survival predictive performance of CSS in immunotherapy. A The fraction of tumor-infiltrating immune cells between CSS-low and CSS-high groups in TCGA cohort by ssGSEA. B Comparison of checkpoints genes expressions (PD-L1, PD-1, and CTLA4) between CSS-low and CSS-high groups. C–E Kaplan–Meier curves for four patient groups stratified by CCS and immune checkpoint genes (PD-L1 (C), PD-1 (D), CTLA4 (E)). F–H IPS(F), TIDE score (G) and T cell Exclusion score (H) were compared between CSS-low and CSS-high subgroups in TCGA cohort. I The comparison of AUC of CSS, TIDE score, and IPS for OS in TCGA cohort. J Kaplan–Meier survival curves for patients with low and high CSS in anti-PD-L1 or anti-PD1-treated lung cohort. The statistical differences between two groups were compared through the Wilcoxon test. ns not significant; *P < 0.05; **P < 0.01; ***P < 0.001