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. 2021 Dec 6;19:406. doi: 10.1186/s12951-021-01154-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The biological functions of ORMDL3⁺ cholangiocytes. a UMAP projections of liver and immune cells colored by ORMDL3⁺ and ORMDL3⁻ cholangiocytes. Blue color represents ORMDL3⁻ cholangiocytes, red color represents ORMDL3⁺ cholangiocytes, and gray color stands for the rest of all other cell types. b UMAP embedding of all cells among 13 cell populations colored by the metabolism activity score of all metabolism-related pathways collected from the KEGG pathway resource. c Violin plot showing the difference in metabolism activity score between ORMDL3⁺ and ORMDL3⁻ cholangiocytes. Two-side Wilcoxon test was used for assessing significance. d Volcano plot showing the differentially expressed genes (DEGs) between ORMDL3⁺ cholangiocytes and ORMDL3⁻ cholangiocytes. Green color represents 71 significantly down-regulated DEGs, and orange color represents 6 significantly up-regulated DEGs. e Pathway enrichment analysis of 71 down-regulated DEGs based on the KEGG pathway resource. f Scatter plot showing the dominant senders (sources) and receivers (targets) in a 2D space. y axis represents incoming interaction strength, and x axis represents outgoing interaction strength. The size of each node represents the count of cellular interactions. g The cellular communications of ORMDL3⁺ Cholangiocyte with other cell populations in liver tissues. The width represents the number of cellular interactions