Fig. 8.

The inferred outgoing (source) communication patterns of cell populations in liver tissue. a Five inferred outgoing communications patterns of 13 cell populations, which shows the correspondence between the inferred latent patterns and cell groups, as well as signaling pathways, b The contribution of signaling pathways among the five outgoing communications patterns to liver and immune cell types. The red dashed box marked the VEGF signaling pathway. c Heatmap showing the relative importance of each cell group based on the computed four network centrality measures of VEGF signaling pathway network. d Violin plot showing the difference in VEGF signaling score between ORMDL3⁺ and ORMDL3⁻ cholangiocytes. The expression levels of all genes in VEGF signaling pathway were used to calculate the VEGF signaling score. Two-side Wilcoxon test was used for assessing significance