Table 1.
Identification of 29 significant risk genes by using integrative genomics analysis
| Gene name | Z score | P value (S-MultiXcan) | FDR (S-MultiXcan) | FDR (S-PrediXcan on liver) | FDR (S-PrediXcan on blood) | FDR (MAGMA analysis of GWAS) | P value (Differential gene expression analysis) | GWAS_Catalog database or PubMed database |
|---|---|---|---|---|---|---|---|---|
| CSNK2B | 1.40 | 7.17 × 10–19 | 8.41 × 10–16 | 3.22 × 10–11 | 2.24 × 10–6 | 1.67 × 10–11 | 4.96 × 10–4 (Blood), 2 × 10–2 (CD14 + T cell) | Novel gene |
| LY6G5B | − 7.92 | 2.43 × 10–16 | 1.93 × 10–13 | 5.52 × 10–11 | 1.54 × 10–10 | 1.19 × 10–11 | Non-significant | Novel gene |
| DDAH2 | − 5.57 | 1.39 × 10–15 | 9.99 × 10–13 | 2.65 × 10–9 | 1.56 × 10–11 | 1.69 × 10–9 | 2.70 × 10–3 (CD14 + T cell) | Novel gene |
| LY6G5C | − 7.82 | 2.40 × 10–15 | 1.62 × 10–12 | 8.64 × 10–13 | 9.05 × 10–12 | 1.41 × 10–11 | 2.80 × 10–2 (Blood) | Novel gene |
| IRF5 | 7.11 | 2.62 × 10–15 | 1.72 × 10–12 | 4.29 × 10–13 | 1.12 × 10–12 | 7.18 × 10–11 | 7.10 × 10–3 (Liver) | Reported gene |
| SOCS1 | − 3.26 | 9.33 × 10–13 | 4.16 × 10–10 | 5.25 × 10–10 | 7.34 × 10–10 | 1.06 × 10–8 | 3.50 × 10–2 (CD14 + T cell) | Reported gene |
| SYNGR1 | − 1.30 | 2.83 × 10–9 | 8.88 × 10–7 | 7.97 × 10–4 | 1.30 × 10–7 | 4.13 × 10–2 | 1.40 × 10–2 (CD14 + T cell) | Reported gene |
| C6orf48 | − 4.46 | 9.57 × 10–9 | 2.66 × 10–6 | 7.83 × 10–4 | 6.19 × 10–4 | 4.83 × 10–11 | 4.16 × 10–6 (Blood) | Novel gene |
| HLA-DMA | − 3.99 | 8.87 × 10–8 | 1.90 × 10–5 | 1.27 × 10–3 | 9.16 × 10–4 | 1.62 × 10–8 | 2.10 × 10–3 (Liver) | Novel gene |
| SMC4 | − 1.34 | 1.00 × 10–7 | 2.10 × 10–5 | 9.38 × 10–5 | 2.25 × 10–6 | 2.07 × 10–4 | 4.80 × 10–4 (Blood) | Novel gene |
| TCF19 | 4.55 | 1.49 × 10–7 | 2.99 × 10–5 | 9.46 × 10–5 | 2.24 × 10–6 | 1.98 × 10–4 | Non-significant | Novel gene |
| ORMDL3 | − 2.92 | 7.07 × 10–7 | 1.22 × 10–4 | 2.35 × 10–3 | 7.38 × 10–5 | 2.33 × 10–6 | 3.5 × 10–2 (Liver) | Reported gene |
| KPNA4 | − 1.22 | 1.07 × 10–6 | 1.82 × 10–4 | 2.10 × 10–2 | 3.58 × 10–3 | 4.67 × 10–4 | 3.40 × 10–3 (CD14 + T cell) | Novel gene |
| MANBA | − 1.45 | 1.48 × 10–6 | 2.35 × 10–4 | 2.46 × 10–6 | 2.39 × 10–2 | 8.30 × 10–8 | 9.67 × 10–5 (Blood) | Reported gene |
| MFSD6 | − 0.32 | 1.61 × 10–6 | 2.51 × 10–4 | 2.55 × 10–2 | 4.57 × 10–2 | 2.06 × 10–3 | 3.60 × 10–2 (Liver) | Novel gene |
| MED1 | − 2.13 | 1.76 × 10–6 | 2.70 × 10–4 | 1.65 × 10–2 | 1.53 × 10–2 | 4.42 × 10–5 | Non-significant | Novel gene |
| IDUA | 3.95 | 2.37 × 10–6 | 3.47 × 10–4 | 3.94 × 10–2 | 3.87 × 10–2 | 8.95 × 10–4 | 8.10 × 10–3 (Blood) | Reported gene |
| DGKQ | 3.24 | 3.86 × 10–6 | 5.37 × 10–4 | 4.90 × 10–4 | 3.36 × 10–4 | 2.35 × 10–4 | 8.34 × 10–7 (Blood) | Reported gene |
| FCRL3 | − 4.40 | 8.14 × 10–6 | 1.07 × 10–3 | 2.84 × 10–3 | 2.84 × 10–3 | 5.81 × 10–4 | Non-significant | Reported gene |
| ZCRB1 | 3.22 | 9.34 × 10–6 | 1.20 × 10–3 | 4.83 × 10–3 | 5.02 × 10–3 | 1.52 × 10–3 | 5.90 × 10–3 (Liver); 2.8 × 10–3 (CD14 + T cell); | Novel gene |
| AGAP5 | − 4.28 | 1.29 × 10–5 | 1.59 × 10–3 | 4.50 × 10–3 | 3.40 × 10–3 | 3.65 × 10–2 | Non-significant | Novel gene |
| CARM1 | − 2.90 | 2.11 × 10–5 | 2.49 × 10–3 | 1.14 × 10–3 | 8.92 × 10–4 | 1.86 × 10–4 | 2.60 × 10–2 (Blood) | Novel gene |
| UBE2D3 | − 4.18 | 2.83 × 10–5 | 3.23 × 10–3 | 2.76 × 10–3 | 5.08 × 10–3 | 5.81 × 10–4 | 3.40 × 10–2 (Blood); 1.6 × 10–4 (CD14 + T cell) | Novel gene |
| NAAA | 4.08 | 6.73 × 10–5 | 6.88 × 10–3 | 1.25 × 10–2 | 6.85 × 10–3 | 7.41 × 10–4 | 3.20 × 10–2 (Liver) | Reported gene |
| SH2B3 | − 1.69 | 1.20 × 10–4 | 1.17 × 10–2 | 2.35 × 10–2 | 1.87 × 10–2 | 2.44 × 10–3 | 1.40 × 10–2 (Blood) | Reported gene |
| CTSH | 1.75 | 2.05 × 10–4 | 1.84 × 10–2 | 8.53 × 10–3 | 3.46 × 10–2 | 2.19 × 10–5 | Non-significant | Novel gene |
| TTC34 | 3.56 | 2.82 × 10–4 | 2.39 × 10–2 | 5.86 × 10–3 | 5.02 × 10–3 | 4.98 × 10–3 | 9.80 × 10–3 (Blood) | Novel gene |
| METTL1 | 2.19 | 3.11 × 10–4 | 2.59 × 10–2 | 4.95 × 10–2 | 3.81 × 10–2 | 1.68 × 10–2 | 5.86 × 10–7 (Blood) | Novel gene |
| TSFM | 3.45 | 3.14 × 10–4 | 2.61 × 10–2 | 4.87 × 10–2 | 3.87 × 10–2 | 1.54 × 10–2 | 2.80 × 10–4 (Blood); 1.5 × 10–3 (CD14 + T cell) | Novel gene |