Table 3.

Change from baseline in fasting ANGPTL3, lipid and lipoprotein levels with treatment

Study parameters Mean (SD)	Baseline	Week 27	Change from baseline (%)
ANGPTL3 (µg/L)	115.4 (28.0)	53.9 (22.8)	-54.7 (9.8)
Triglycerides (mmol/L)	9.2 (4.9)	3.4 (3.0)	-59.9 (26.3)
Apo C-III (g/L)	0.3 (0.1)	0.1 (0.1)	-50.9 (27.4)
VLDL-C (mmol/L)	2.7 (1.0)	1.3 (0.8)	-53.5 (18.6)
Non-HDL-C (mmol/L)	5.8 (0.6)	4.6 (1.4)	-20.9 (17.7)
Total cholesterol (mmol/L)	6.4 (0.5)	5.3 (1.3)	-17.7 (14.8)
LDL-C (mmol/L)	2.9 (1.0)	3.3 (0.9)	19.2 (16.1)
HDL-C (mmol/L)	0.7 (0.1)	0.7 (0.2)	8.4 (26.0)
Apo B (µmol/L)	2.4 (0.5)	2.5 (0.6)	1.5 (24.0)
Apo B48 (mg/L)	51.1 (5.6)	15.1 (8.9)	-69.2 (19.8)
Free fatty acids (mmol/L)	1.1 (0.8)	0.5 (0.4)	-41.7 (40.6)

ANGPTL3 Angiopoietin like 3, Apo Apolipoprotein, VLDL-C Very-low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol