Table 4.
Changes in area under the curve from baseline during the mixed meal test in different metabolic parameters during the study
| AUC | Baseline | Week 13 | Week 27 | Change from baseline to week 27 (%) |
|---|---|---|---|---|
| Triglycerides (mg/dL*min) | 199120.0 (96813.0) | 94270.0 (49145.2) | 88022.5 (75031.1) | -60.1 (26.5) |
| Free Fatty Acids (mmol/L*min) | 215.8 (55.2) | 211.9 (75.5) | 144.2 (65.4) | -32.1 (21.4) |
|
Glucose (mg/dL*min)a |
76882.5 (16771.4) | 65265.0 (11720.3) | 64558.7 (11431.1) | -14.0 (5.2) |
|
Insulin (mIU/L*min)a |
18790.1 (2499.7) | 26972.7 (12877.3) | 23440.0 (5329.6) | 16.7 (19.1) |
|
C peptide (ng/mL*min)a |
1761.5 (498.9) | 1580.5 (890.9) | 1484.1 (698.6) | -11.6 (16.6) |
Conversion factor for SI units: Triglyceride=0.0113 (mmol/L); glucose=0.0555 (mmol/L); insulin=6 (pmol/L); C peptide=0.33 (nmol/L)
Data are presented as mean (SD). AUC area under the curve, SD standard deviation
aOne patient (008) with unstable and difficult to control diabetes requiring treatment with high doses of U500 insulin was excluded from analysis of FPG and parameters related to circulating insulin