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. 2021 Nov;191(11):1856–1870. doi: 10.1016/j.ajpath.2021.03.015

Figure 2.

Figure 2

Illustration of neuropathologic features in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). A: Sagittal 3-T magnetic resonance imaging (MRI) fluid-attenuated inversion recovery image in a 52-year–old patient with CADASIL, showing widespread white matter hyperintensity, lacunes, and atrophy. B: Representative hematoxylin and eosin (H&E) staining of the basal ganglia of a deceased patient with CADASIL, showing vessel wall thickening and dilated perivascular spaces. C: H&E staining of the basal ganglia of a deceased patient with CADASIL, showing ischemic lesions and white matter rarefication. MRI image kindly provided by Dr. Yakeel Quiroz (Massachusetts General Hospital, Boston, MA), and postmortem histopathologic images kindly provided by Dr. Diego Sepulveda-Falla (Institut für Neuropathologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany). Scale bars: 100 μm (B); 730 μm (C).