Figure 3.
Notch3 signaling thresholds model. A: Hypothetical model of the Notch3 signaling Goldilocks based on previously published analysis of the effect of Notch3 hypoactivation and hyperactivation on mural cell survival. States of hypoactivation or hyperactivation in Notch3 signaling were associated with mural cell degeneration and apoptosis (Arboleda-Velasquez et al,16). The optimal level of Notch3 signaling, associated with a state of cell survival, is illustrated by dashed lines. B: Candidate genes found to be specifically responsive to each signaling state of the Notch3 Goldilocks are listed (Arboleda-Velasquez et al,16).