Table 1.

Patient cohort characteristics and comorbid conditions

Characteristic	Value
Age (years), Mean (SD)	45.4 (20.1)
18–19 years old	9.2%
20–24 years old	14.7%
25–34 years old	13.0%
35–44 years old	12.6%
45–54 years old	14.0%
55–64 years old	15.3%
65–74 years old	13.2%
75+ years old	8.1%
Gender: Female	57.2%
Post-index follow-up time, Mean (SD)	265.0 (127.0)
Proportion of patients with at least __ days of follow-up:
≥ 30	95.0%
≥ 180	71.2%
≥ 365	51.5%
Charlson comorbidity index score, Mean (SD)	2.09 (3.14)
Comorbid conditions (1-year pre-index period)
Anxiety disorder	40.7%
Essential hypertension	36.4%
Hyperlipidemia	24.2%
Chest pain	21.1%
Low back pain	20.9%
Substance use disorder (not incl. nicotine)	19.8%
Abdominal pain	18.3%
Dyspnea	17.9%
Headache	15.6%
Gastroesophageal reflux disease	15.4%
Insomnia	14.1%
Nicotine dependence	14.0%
Chronic pain	13.8%
Urinary tract infectious disease	12.9%
Neck pain	12.5%
Fatigue	12.5%
Vitamin D deficiency	12.0%
Type 2 diabetes mellitus without complication	12.0%
Obesity	11.1%
Anemia	10.1%