Table 3.
Baseline clinical and laboratory features
| Characteristics | Arm 1: HCQ + SOC |
Arm 2: SOC alone |
Total |
|---|---|---|---|
| Number randomized | 55 | 50 | 105 |
| Body mass index (BMI) in kgs/m2 a | |||
| Number of observations | 55 | 49 | 104 |
| Mean (standard deviation) | 30.8 (7.5) | 31.3 (7.3) | 31.0 (7.4) |
| BMI categories | |||
| < 18.5 | 1 (1.8) | 1 (2.0) | 2 (1.9) |
| 18.5 to < 25 (normal) | 13 (23.6) | 9 (18.4) | 22 (21.2) |
| 25 to < 30 (over-weight) | 14 (25.5) | 12 (24.5) | 26 (25.0) |
| ≥ 30 (obese) | 27 (49.1) | 27 (55.1) | 54 (51.9) |
| ECG QTc interval (ms) | |||
| Overall–mean (SD) | 417 (22) | 409 (20) | 413 (22) |
| Males–mean(SD) | 410 (22) | 404 (19) | 407 (21) |
| Females–mean(SD) | 430 (15) | 423 (16) | 427 (16) |
| Serum Potassium (mmols/L) | |||
| Number of observations | 52 | 41 | 93 |
| Mean (SD) | 4.6 (0.9) | 4.6 (0.7) | 4.6 (0.8) |
| Visual color test, (%) | |||
| Normal | 54 (94.7) | 50 (100.0) | 104 (97.2) |
| Abnormal | 3 (5.3) | 0 | 3 (2.8) |
| Pulse rate (beats/min), median (IQR) | 78 (70–86) | 78 (67–85) | 78 (68–86) |
| Visual acuity–left eye, n (%) | |||
| 6/6 | 42 (76.4) | 37 (77.1) | 79 (76.7) |
| 5/6 | 4 (7.3) | 1 (2.1) | 5 (4.9) |
| 4/6 | 2 (3.6) | 0 | 2 (1.9) |
| 20/30 | 6 (10.9) | 8 (16.7) | 14 (13.6) |
| 6/12 | 1 (1.8) | 1 (2.1) | 2 (1.9) |
| 6/18 | 0 | 1 (2.1) | 1 (1.0) |
| Visual acuity–right eye, n (%) | |||
| 6/6 | 43 (75.4) | 38 (82.6) | 81 (78.6) |
| 5/6 | 5 (8.8) | 0 | 5 4.9) |
| 4/6 | 2 (3.5) | 1 (2.2) | 3 (2.9) |
| 6/12 | 0 | 1 (2.2) | 1 (1.0) |
| 20/30 | 7 (12.3) | 6 (13.0) | 13 (12.6) |
aMissing values: BMI, 1 (0.95%)