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. 2021 Nov 22;12:733171. doi: 10.3389/fimmu.2021.733171

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Copyright © 2021 Zhang, Feng, Tam, Wang and Feng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of SARS-CoV-2 infection on the intramodular correlation of co-expression gene modules in nasal swabs and lung tissues. (A, E) A pairwise association of gene modules in a topological overlap plot. (B, F) Geometric data analysis in 3D scattering. (C, G) t-SNE dimension reduction analysis to observe the distribution of gene modules. (D, H) Pairwise illustration of gene module correlation profile indicated by Pearson’s R shown in whole pairwise scatterplots in color with p-value in the lower panel (one-way ANOVA with Tukey’s multiple comparison).