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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Curr Opin Hematol. 2022 Jan 1;29(1):34–43. doi: 10.1097/MOH.0000000000000692

Figure 1. General overview of lncRNA mechanisms involved in AML.

Figure 1

(A) LncRNAs can act as a guide to target chromatin-modifying complexes or transcription factors to specific genomic locations and affect the target gene expression. (B) LncRNAs can serve as transcriptional regulators that can either recruit or prevent transcriptional factors to the enhancers and promoters of target genes, thereby regulating target gene expression. (C) In the cytoplasm, lncRNAs can sequester microRNAs away from their mRNA targets thereby affecting the target gene expression.