Table 1:

Summary of lncRNAs recently reported in AML

	LncRNAs	Expression in AML	Key findings/mechanism(s) of action	References
LncRNAs associated with NPM1 mutation	HOXB-AS3	upregulated	Guides EBP1 protein to rDNA locus Facilitates the interaction of EBP1 with residual NPM1 in nucleolus and maintains adequate amount of rRNA thereby maintaining the proliferative state in leukemic cells by translation of the necessary metabolic proteins	(20)
	HOXBLINC	upregulated	Overexpression maintains aberrant NPM1c+ signature gene expression program via controlling the MLL1 recruitment Acts as an epigenetic regulator by remodelling promoter chromatin accessibility in cis and trans actions	(23)
	LONA	upregulated	Promotes leukemogenesis via nucleocytoplasmic cross-transport between mutant NPM1 and LONA Modulates key genes involved in myeloid cell differentiation	(26)
	CRNDE	upregulated	sponges miR-181 and regulates NOTCH2 in acute promyelocytic cells	(28)
LncRNAs associated with RUNX1	CASC15	upregulated	Affects the expression of nearby oncogene-SOX4 by regulating YY1 transcription factor	(33)
	LOUP	Downregulated in t(8;21) AML patients	Myeloid specific lncRNA, cooperates with RUNX1 to induce PU.1 expression thereby promoting myeloid differentiation and inhibiting cell growth LOUP is inhibitory target of RUNX1-ETO in t(8;21) AML	(39)
LncRNAs associated with FLT3-ITD, TET2 mutations	Morrbid	Upregulated in AML patients with FLT3-ITD, TET2 mutations	Loss of Morrbid increases expression of Bim which induces apoptosis	(44)
	SOCS2-AS	Upregulated in AML patients with FLT3-ITD mutation	Targets the miR-221/STAT5 signaling pathway	(45)
LncRNAs associated with MLL- rearranged leukemia	LAMP5-AS1	upregulated	Maintains high methyltransferase activity of DOT1L thereby upregulating DOT1L target genes	(50)
	HOXA10-AS	upregulated	HSC-specific lncRNA, acts in trans to induce NF-kB target genes	(51)