Table 1.

Summary of microRNAs and their roles in mitochondria

miR	miR accession number	Target genes	Gene accession number	Function	Functional pathway	Location	Species	References
miR-378	MI0000795	Crat	ENSMUSG00000026853	Downregulation	Mitochondrial oxidative metabolism	Mitochondria in liver cells	Mouse	Carrer et al., 201259
miR-24	MI0000080	H2ax	ENSMUSG00000049932	Downregulation	Insulin pathway signaling	Mitochondria liver cells in	Human	Jeong et al., 201761
miR-23b	MI0000439	GLS	ENSG00000115419	Downregulation	Glutamine metabolism	LMitochondria liver cells in	Human	Gao et al., 200960
		SLC2A1	ENSG00000117394	Downregulation
miR-1291	MI0006353	CPT1C ESRRA	ENSG00000169169 ENSG00000173153	Downregulation Downregulation	Mitochondrial	Mitochondria in	Human	Yamasaki et al., 2013; Chen et al.,
		ASS1	ENSG00000130707	Downregulation	metabolism	renal cells		2020, Tu et al., 202063, 64, 65
		GLUT1	ENSG00000117394	Downregulation
miR-138	MI0000455	PDK1	ENSG00000152256	Downregulation	Glucose metabolism	Mitochondria in cardiac cells	Human	Zhu et al., 201766
miR-150	MI0000920 MI0000479	Slc2a4 SLC2A1	ENSRNOG00000017226 ENSG00000117394	Downregulation Downregulation	Metabolism	Mitochondria in cardiac cells	Rat Human	Ju et al., 202067 Li et al., 201768
		Slc2a4	ENSRNOG00000017226	Upregulation		Mitochondria in
miR-199a	MI0000941	Hk2	ENSRNOG00000006116	Upregulation	Expression of	muscle cells	Rat	Esteves et al., 2018, Yan et al., 2014, Guo
	MI0000242	HK2	ENSG00000159399	Upregulation	glucose transporters	Mitochondria in liver cells	Human	et al., 20154, 69, 70
miR-532-5p	MI0006154	SlcHk22 a4	ENSRNOGENSRNOG00000017226 00000006116	Upregulation Upregulation	Expression glucose transporters of	Mitochondria muscle cells in	Rat	Esteves et al., 201870
					Mitochondrial	Mitochondria in
miR-29a	MI0000576	Slc16a1	ENSMUSG00000032902	Downregulation	oxidative metabolism	pancreatic betacells	Mouse	Pullen et al., 201171
miR-29b	MI0000143	Slc16a1	ENSMUSG00000032902	Downregulation	Mitochondrial oxidative metabolism	Mitochondria in pancreatic betacells	Mouse	Pullen et al., 201171
					Mitochondrial	Mitochondria in
miR-124	MI0000716	Slc16a1	ENSMUSG00000032902	Downregulation	oxidative	pancreatic beta-	Mouse	Pullen et al., 201171
					metabolism	cells
		CROT	ENSANAG00000028065	Downregulation
		CPT1A	ENSANAG00000017356	Downregulation
		HADHB	ENSANAG00000027802	Downregulation
		PRKAA1	ENSANAG00000032687	Downregulation
miR-33a/b	a-MI0002684, b-MI0007603	ABCA1	ENSANAG00000033387	Downregulation	Lipid metabolism	Mitochondria in liver cells	Monkey	Rayner et al., 201172
		SREBF1	ENSANAG00000021477	Upregulation
		FASN	ENSANAG00000032055	Upregulation
		ACLY	ENSANAG00000036009	Upregulation
		ACACA	ENSANAG00000035253	Upregulation
miR-143	MI0000916	Map2k5	ENSRNOG00000007926	Downregulation	Adipogenesis	Mitochondria in adipose cells	Rat	Chen et al., 201473
	MI0000459	APOL6	ENSG00000221963	Downregulation	Adpiogenesis	Mitochondria in adipose cells	Human	Ye et al., 201374
miR-204	MI0000284	ACACB	ENSG00000076555	Downregulation	Lipid metabolism	Mitochondria adipose cells in	Human	Civelek et al., 201375
miR-200	MI0000737	ZEBZEB1 2	ENSGENSG00000148516 00000169554	Upregulation Upregulation	Lipid metabolism	Mitochondria breast cells in	Human	Ahmad et al., 201176
miR-338	MI0000618	COXIV	ENSRNOG00000007827	Downregulation	Mitochondria oxidative metabolism	Mitochondria in neural cells	Rat	Aschrafi et al., 200877
miR-181c	MI0000924	COX1	ENSRNOG00000034234	Downregulation	Mitochondria oxidative metabolism	Mitochondria in cardiac cells	Rat	Das et al., 201288
miR-210	MI0000268	ISCU	ENSG00000136003	Downregulation	Mitochondria oxidative metabolism	Mitochondria in placenta cells	Human	Colleoni et al., 2013; Qiao et al., 201381, 85
miR-15b	MI0000843	Arl2	ENSRNOG00000021010	Downregulation	ATP production	Mitochondria in cardiac cells	Rat	Nishi et al., 201082
		Bcl2	ENSRNOG00000002791	Downregulation
miR-16	MI0000844	Bcl2	ENSRNOG00000002791	Downregulation	ATP production	Mitochondria in cardiac cells	Rat	Nishi et al., 201082
		Arl2	ENSRNOG00000021010	Downregulation
miR-195	MI0000939	Arl2	ENSRNOG00000021010	Downregulation	ATP production	Mitochondria in cardiac cells	Rat	Nishi et al., 201082
miR-29a-3p	MI0000576	Foxa2	ENSMUSG00000037025	Upregulation	Lipid metabolism	Mitochondria liver cells in	Mouse	Kurtz et al., 201486
miR-19b	MI0000074	MFN1	ENSG00000171109	Downregulation	Apoptosis	Mitochondria in bone cells	Human	Li et al., 201487
miR-101-3p	MI0000103	ATP5B	ENSG00000110955	Silencing	Mitochondria metabolism	Mitochondria heLa cells in	Human	Zheng et al., 201184