Table 2.

Summary of mitomiRs with roles in cancer

miR	miR accession number	Target genes	Gene accession number	Function	Functional pathway	Type of cancer	Species	References
		HIF-1	ENSG00000258777	Upregulation
		ISCU	ENSG00000136003	Upregulation
miR-210	MI0000286	COX10	ENSG00000006695	Upregulation	Hypoxia	Breast cancer, neck and head cancer, lung cancer	Human	Qin et al., 2014; Gee et al., 2010; Puissegur et al., 2011109, 110, 111
		SDHD	ENSG00000204370	Upregulation
		NDUFA4	ENSG00000189043	Upregulation
miR-200a	MI0000342	TFAM	ENSG00000108064	Downregulation	Mitochondrial biogenesis, cancer metabolism	Breast cancer	Human	Yao et al., 2014112
miR-155	MI0000681	HK2	ENSG00000159399	Upregulation	phosphorylation Glucose	Breast cancer	Human	Jiang Fang et et al.al., , 20122012; 104
miR-124	MI0000443	PKM	ENSG00000067225	Upregulation	metabolism Glucose	Colorectal cancer	Human	Sun et al., 2012105
miR-137	MI0000454	PKM	ENSG00000067225	Upregulation	metabolism Glucose	Colorectal cancer	Human	Sun et al., 2012105
miR-340	MI0000802	PKM	ENSG00000067225	Upregulation	metabolism Glucose	Colorectal cancer	Human	Sun et al., 2012105
miR-326	MI0000808	PKM2	ENSG00000067225	Downregulation	metabolism Glucose	Glioblastoma	Human	Kefas et al., 2010106
miR-181-5p	MIMAT0000256	RASSF6 INPP5A	ENSG00000169435 ENSG00000068383	Downregulation Downregulation	Mitogen-activated protein kinase (MAPK) signaling pathway	Gastric cancer, cervical cancer	Human	Mi et al., 2017; Zhuang et al., 2017108, 113
miR-92a-1	MI0000093	BCL2L11	ENSG00000153094	Downregulation	Apoptosis	Lymphoma	Human	Mogilyansky Rigoutsos, 2013 and 94
		PIK3R2	ENSG00000105647	Downregulation		Breast cancer cells		Zhu et al., 2011114
		PLK2	ENSG00000260410	Downregulation		Acute leukaemia cells		Li et al., 2008115
		EGFL7	ENSG00000172889	Downregulation		Oral squamous cells		Sasahira et al., 2012116
		CRK	ENSG00000167193	Downregulation		Lung cancer cells		Crawford 2008117 et al.,
		ADAM9	ENSG00000168615	Downregulation		Melanoma cells cancer		Felli et al., 2013118
miR-126	MI0000471	HOXA9	ENSG00000078399	Downregulation	Inflammation, angiogenesis	Acute leukaemia cells	Human	Shen et al., 2008119
		IRS1	ENSG00000169047	Downregulation		Breast cancer cells		Zhang et al., 2008120
		SOX-2	ENSG00000242808	Downregulation		Gastric cells cancer		Otsubo et al., 2011121
		SLC7A5	ENSG00000103257	Downregulation		Lung cancer cells		Miko et al., 2011122
		VEGFA	ENSG00000150630	Downregulation		Oral squamous cells		Sasahira et al., 2012116
		MMP7	ENSG00000137673	Downregulation		Melanoma cells cancer		Felli et al., 2013118
		BCL-2	ENSG00000171791	Downregulation
								Gao et al., 2010101
		MCL-1	ENSG00000143384	Downregulation
		COX4I2	ENSG00000131055	Downregulation
miR-15a	MI0000069	COX6A2	ENSG00000156885	Downregulation	Apoptosis, ATP production	B-cell chronic lymphocytic leukemia	Human	Siengdee et al.,
		NDUFB7	ENSG00000099795	Downregulation				2010102
		NDUFV1	ENSG00000167792	Downregulation
		NDUFS4	ENSG00000164258	Downregulation
		COX4I2	ENSG00000131055	Downregulation
		COX6A2	ENSG00000156885	Downregulation
miR-16a	MI0000070	NDUFB7	ENSG00000099795	Downregulation	Apoptosis, ATP production	B-lymphocytic cell chronic leukemia	Human	Siengdee et al., 2010102
		NDUFV1	ENSG00000167792	Downregulation
		NDUFS4	ENSG00000164258	Downregulation