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. Author manuscript; available in PMC: 2022 Dec 7.
Published in final edited form as: J Am Coll Cardiol. 2021 Dec 7;78(23):2354–2376. doi: 10.1016/j.jacc.2021.09.1367

Central Illustration. Over-arching Approach to Evaluate Medical Therapy for Calcific Aortic Stenosis.

Central Illustration.

Scientific advances in key areas combined with collaboration across multiple stakeholders (facilitated by the Heart Valve Collaboratory) could establish a clinical trial network purpose-fit to implement a platform trial to identify and validate effective and safe medical therapies for progressive aortic stenosis. AS, aortic stenosis; AVA, aortic valve area; AVC, aortic valve calcification; EMR, electronic medical record; FDA, Food and Drug Administration; NaF, sodium fluoride; NIH, National Institutes of Health.