Figure 6.

Genes hypermethylated in cancer are more likely to be PRC2 targets in ESCs. (A,B) Percentage of genes, within each of the four classes of genes defined in human ESCs, whose promoters are aberrantly DNA hypermethylated (A) or hypomethylated (B) in various cancer types. All the P-values were calculated using Fisher's exact test. (C) Log₂ odds ratio, with 95% confidence intervals, of promoter DNA hypermethylation (left) or hypomethylation (right) in various cancer types based on their chromatin state in human ESCs.