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. 2021 Dec;31(12):2185–2198. doi: 10.1101/gr.264705.120

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© 2021 Hong et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 4. — EBNA2-dependent alteration of the human chromatin landscape. (A) EBNA2 binding and EBNA2-dependent chromatin opening at the promoter of the up-regulated EBNA2 DEG NAALADL2-AS2, the most up-regulated EBNA2 DEG (UCSC Genome Browser screenshot [hg19]). (B,C) EBNA2-dependent alteration of chromatin looping at the SLAMF1 locus. (B) EBNA2-dependent looping to the promoter of the EBNA2 DEG SLAMF1. Loops outside the window are not shown. (C) Extensive EBNA2-dependent rewiring of the chromatin looping landscape at the SLAMF1 locus.