FIGURE 3.

Intestinal epithelial GR is required for alcohol‐ and corticosterone‐induced mucosal inflammatory response in the colon. Adult GR^ΔHC and GR^ΔIEC mice were fed a liquid diet with (EF) or without (PF) ethanol for 4 weeks. In some groups, animals were injected with corticosterone (Cort) daily; the other groups received the vehicle. RNA isolated from colonic mucosa was analyzed for mRNA specific for TNFα (A), IL‐1β (B), IL‐6 (C), and MCP1 (D) by RT‐qPCR. Values are mean ± SEM (n = 6); *p < .05, **p < .01, ***p < .005, and ****p < .001 for significant difference between the indicated groups; ns, not significant