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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Nature. 2021 Sep 23;599(7885):513–517. doi: 10.1038/s41586-021-04022-z

Extended Data Fig. 2. 3D reconstruction of native GlyRs.

Extended Data Fig. 2

a, A typical cryo-EM micrograph for native GlyRs. The experiments were repeated three times with similar results. b, Selected 2D class averages for native GlyR-Fab complex. c, Flow chart for cryo-EM data analysis of native GlyRs. d, f, h, j, Local resolution maps for unsharpened heteromeric pentamer (d), homomeric α tetramer (f), locally refined ECD (h) and TMD map (j) of homomeric pentamer. e, g, i, k, FSC curves for heteromeric pentamer (e), homomeric α tetramer (g), locally refined ECD (i) and TMD map (k) of homomeric α pentamer.