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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Gynecol Oncol. 2021 Apr 16;162(1):163–172. doi: 10.1016/j.ygyno.2021.04.015

Figure 6. Graphical summary indicating the mechanism for entinostat-induced olaparib sensitivity in HR-proficient cells.

Figure 6.

As described, entinostat causes breakdown of HR-DNA repair pathway, whereas olaparib inactivates PARP, crippling the cell’s potential to repair SSBs. This in turn leads to accumulation of DSBs, which the cell is unable to repair due to defective HR repair pathway, accumulating unrepaired DNA ultimately resulting in cell death.