Table 4.
Associations between in utero (cord blood) chlordecone exposure and thyroid hormone concentrations at seven years of age in children of the TIMOUN cohort.
| Hormone | Sex (N) | Chlordecone (µg/L) | Unadjusted | Adjusted a | ||||
|---|---|---|---|---|---|---|---|---|
| ß b | 95% CI | P | ß b | 95% CI | P | |||
| TSH b (mIU/L) (log10) | Boys (124) | <0.07 | Ref. | Ref. | ||||
| 0.07-0.19 | 0.12 | -0.12; 0.36 | 0.32 | 0.20 | -0.04; 0.44 | 0.10 | ||
| 0.20-0.40 | 0.01 | -0.21; 0.23 | 0.92 | 0.05 | -0.17; 0.26 | 0.68 | ||
| >0.40 | 0.02 | -0.20; 0.24 | 0.85 | 0.10 | -0.13; 0.33 | 0.38 | ||
| Log10 | -0.01 | -0.07; 0.04 | 0.71 | -0.01 | -0.05; 0.06 | 0.82 | ||
| Girls (159) | <0.07 | Ref. | Ref. | |||||
| 0.07-0.19 | 0.10 | -0.11; 0.32 | 0.34 | 0.10 | -0.11; 0.32 | 0.51 | ||
| 0.20-0.40 | 0.19 | -0.02; 0.40 | 0.08 | 0.22 | 0.01; 0.44 | 0.04 | ||
| >0.40 | 0.05 | -0.16; 0.27 | 0.63 | 0.08 | -0.15; 0.30 | 0.50 | ||
| Log10 | 0.02 | -0.04; 0.07 | 0.53 | 0.02 | -0.03; 0.08 | 0.39 | ||
| FT3 b (pmol/mL) (log10) | Boys (124) | <0.07 | Ref. | Ref. | ||||
| 0.07-0.19 | -0.32 | -0.93; 0.28 | 0.29 | -0.22 | -0.76; 0.32 | 0.43 | ||
| 0.20-0.40 | 0.14 | -0.42; 0.70 | 0.62 | 0.03 | -0.46; 0.52 | 0.92 | ||
| >0.40 | 0.24 | -0.33; 0.81 | 0.41 | -0.06 | -0.57; 0.44 | 0.80 | ||
| Log10 | 0.11 | -0.03; 0.26 | 0.11 | 0.05 | -0.08; 0.17 | 0.45 | ||
| Girls (161) | <0.07 | Ref. | Ref. | |||||
| 0.07-0.19 | 0.30 | -0.23; 0.83 | 0.27 | 0.32 | -0.21; 0.85 | 0.24 | ||
| 0.20-0.40 | 0.37 | -0.15; 0.89 | 0.16 | 0.42 | -0.11; 0.94 | 0.12 | ||
| >0.40 | 0.18 | -0.36; 0.71 | 0.52 | 0.18 | -0.36; 0.73 | 0.51 | ||
| Log10 | 0.07 | -0.07; 0.20 | 0.33 | 0.08 | -0.06; 0.22 | 0.27 | ||
| FT4 b (pmol/mL) (log10) | Boys (124) | <0.07 | Ref. | Ref. | ||||
| 0.07-0.19 | -0.32 | -1.15; 0.50 | 0.44 | -0.22 | -1.08; 0.63 | 0.61 | ||
| 0.20-0.40 | -0.18 | -0.95; 0.58 | 0.63 | -0.25 | -1.00; 0.51 | 0.52 | ||
| >0.40 | -0.28 | -1.06; 0.50 | 0.48 | -0.35 | -1.12; 0.41 | 0.36 | ||
| Log10 | 0.04 | -0.15; 0.23 | 0.69 | 0.02 | -0.17; 0.21 | 0.83 | ||
| Girls (161) | <0.07 | Ref. | Ref. | |||||
| 0.07-0.19 | -0.22 | -1.06; 0.62 | 0.60 | -0.13 | -0.95; 0.69 | 0.76 | ||
| 0.20-0.40 | 0.08 | -0.75; 0.90 | 0.86 | 0.21 | -0.61; 1.02 | 0.61 | ||
| >0.40 | 0.35 | -0.50; 1.20 | 0.42 | 0.52 | -0.32; 1.35 | 0.23 | ||
| Log10 | 0.11 | -0.10; 0.32 | 0.30 | 0.17 | -0.04; 0.38 | 0.12 | ||
a
The covariates for which we adjusted: For TSH boys: mothers’ BMI in early pregnancy, alcohol during pregnancy; For TSH girls: alcohol during pregnancy, breastfeeding; For FT3 boys: geographic origin, mothers’ age at delivery, breastfeeding, alcohol during pregnancy; For FT3 girls: geographic origin, mothers age at delivery, alcohol during pregnancy; For FT4 boys: mothers’ age at delivery, breastfeeding, z-BMI; For FT4 girls: z-BMI.
b
Beta coefficient of regression.