Table 6.

Associations between in utero (cord blood) chlordecone exposure and steroid hormone concentrations at seven years of age in children of the TIMOUN cohort.

Hormone	Sex(N)	Chlordecone (µg/L)	Unadjusted			Adjusted a
			ß b or OR c	95% CI	P	ß b or OR c	95% CI	P
DHEA b (nmol/L) (log10)	Boys (124)	<0.07	Ref.			Ref.
		0.07-0.19	0.20	-0.31; 0.72	0.44	0.26	-0.24; 0.75	0.30
		0.20-0.40	0.54	0.06; 1.03	0.03	0.54	0.08; 1.01	0.02
		>0.40	0.37	-0.12; 0.86	0.13	0.39	-0.08; 0.86	0.11
		Log10	0.05	-0.08; 0.17	0.47	0.04	-0.08; 0.16	0.51
	Girls (161)	<0.07	Ref.			Ref.
		0.07-0.19	0.20	-0.16; 0.55	0.27	0.18	-0.17; 0.52	0.32
		0.20-0.40	0.41	0.06; 0.75	0.02	0.36	0.02; 0.71	0.04
		>0.40	0.29	-0.07; 0.64	0.11	0.22	-0.13; 0.57	0.21
		Log10	0.09	0.004; 0.18	0.04	0.08	-0.01; 0.16	0.09
DHT c (<LOD vs ≥ LOD)	Boys (124)	<0.07	Ref.			Ref.
		0.07-0.19	1.97	0.67; 5.78	0.22	1.81	0.61; 5.39	0.29
		0.20-0.40	3.69	1.29; 10.56	0.02	3.70	1.29; 10.6	0.02
		>0.40	1.16	0.43; 3.15	0.77	1.17	0.43; 3.19	0.76
		Log10	0.99	0.77; 1.28	0.96	0.99	0.77; 1.28	0.96
	Girls (161)	<0.07	Ref.			Ref.
		0.07-0.19	0.80	0.31; 2.03	0.63	0.81	0.31; 2.17	0.68
		0.20-0.40	2.64	0.88; 7.90	0.08	3.20	1.01; 10.2	0.05
		>0.40	1.05	0.40; 2.79	0.92	1.13	0.41; 3.15	0.81
		Log10	1.07	0.83; 1.37	0.63	1.08	0.83; 1.41	0.57
Testosterone c (<LOD vs ≥ LOD)	Boys (124)	<0.07	Ref.			Ref.
		0.07-0.19	1.02	0.34; 3.04	0.97	1.07	0.32; 3.58	0.91
		0.20-0.40	2.29	0.84; 6.23	0.11	3.22	1.08; 9.58	0.04
		>0.40	0.94	0.33; 2.63	0.90	1.33	0.43; 4.07	0.62
		Log10	1.03	0.80; 1.33	0.82	1.12	0.85; 1.47	0.43
	Girls (161)	<0.07	Ref.			Ref.
		0.07-0.19	1.67	0.68; 4.06	0.26	1.89	0.76; 4.72	0.17
		0.20-0.40	3.11	1.27; 7.62	0.01	3.28	1.32; 8.17	0.01
		>0.40	2.09	0.83; 5.09	0.12	1.96	0.78; 4.88	0.15
		Log10	1.27	1.01; 1.61	0.04	1.25	0.98; 1.59	0.07
Estradiol c (<LOD vs ≥ LOD)	Boys (124)	<0.07	Ref.			Ref.
		0.07-0.19	0.70	0.17; 2.81	0.61	0.65	0.16; 2.65	0.55
		0.20-0.40	1.10	0.33; 3.61	0.88	1.14	0.34; 3.81	0.83
		>0.40	1.03	0.30; 3.52	0.96	1.05	0.30; 3.61	0.94
		Log10	0.99	0.73; 1.36	0.96	1.00	0.73; 1.37	0.99
	Girls (161)	<0.07	Ref.			Ref.
		0.07-0.19	0.67	0.27; 1.62	0.37	0.72	0.29; 1.77	0.47
		0.20-0.40	1.26	0.53; 3.00	0.60	1.36	0.56; 3.26	0.50
		>0.40	0.90	0.37; 2.19	0.82	0.88	0.36; 2.16	0.78
		Log10	1.05	0.84; 1.31	0.70	1.03	0.82; 1.30	0.78

^aThe covariates for which we adjusted: For DHEA boys: child z-score BMI; For DHEA girls: geographical origin; For DHT boys: breastfeeding; For DHT girls: mothers’ age at delivery, smoking during pregnancy, child z-score BMI; For Testosterone boys: geographical origin, alcohol during pregnancy, breastfeeding; For testosterone girls: geographical origin, mothers’ age at delivery; For Estradiol boys: mothers’ BMI in early pregnancy; For estradiol girls: mothers’ age at delivery.

^bBeta coefficient of regression;

^cOdds ratio.