TABLE 5.
Results of multivariate analysis.
| Functional outcome | Mortality | Hemorrhagic transformation | ||||||||
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| P-value | OR | 95%CI | P-value | OR | 95%CI | P-value | OR | 95%CI | ||
| Model 1 | ln(NT-proBNP) | <0.001 | 1.36 | 1.16–1.59 | <0.001 | 1.68 | 1.27–2.24 | <0.001 | 1.42 | 1.18–1.72 |
| Gender | 0.170 | 1.40 | 0.87–2.26 | 0.495 | 1.36 | 0.56–3.31 | 0.115 | 1.65 | 0.89–3.07 | |
| Age | 0.823 | 1.00 | 0.98–1.02 | 0.802 | 1.01 | 0.97–1.05 | 0.474 | 0.99 | 0.97–1.02 | |
| BMI | 0.100 | 1.07 | 0.99–1.15 | 0.731 | 1.02 | 0.89–1.17 | 0.318 | 1.05 | 0.96–1.15 | |
| ONT | 0.130 | 1.00 | 1.00–1.01 | 0.503 | 1.00 | 0.99–1.01 | 0.164 | 1.00 | 1.00–1.01 | |
| Dosage 0.9 mg/kg | 0.539 | 1.17 | 0.71–1.92 | 0.595 | 1.28 | 0.52–3.17 | 0.406 | 1.30 | 0.70–2.42 | |
| Bridging therapy | 0.681 | 1.15 | 0.60–2.20 | 0.455 | 0.61 | 0.17–2.22 | 0.011 | 2.41 | 1.22–4.75 | |
| NIHSS | <0.001 | 1.10 | 1.05–1.14 | <0.001 | 1.09 | 1.05–1.15 | 0.878 | 1.00 | 0.96–1.04 | |
| Model 2 | ln(NT-proBNP) | <0.001 | 1.62 | 1.37–1.91 | <0.001 | 1.75 | 1.31–2.32 | <0.001 | 1.43 | 1.18–1.74 |
| Smoking | 0.060 | 0.63 | 0.39–1.02 | 0.045 | 2.61 | 1.02–6.63 | 0.707 | 1.13 | 0.60–2.13 | |
| Drinking | 0.069 | 1.57 | 0.97–2.54 | 0.732 | 0.85 | 0.34–2.14 | 0.002 | 2.70 | 1.43–5.12 | |
| AF | 0.014 | 0.40 | 0.19–0.83 | 0.293 | 1.73 | 0.62–4.83 | 0.624 | 1.23 | 0.53–2.84 | |
| CHD | 0.327 | 0.77 | 0.45–1.30 | 0.915 | 1.05 | 0.43–2.54 | 0.096 | 0.56 | 0.28–1.11 | |
| Hypertension | 0.381 | 1.23 | 0.77–1.96 | 0.607 | 0.78 | 0.31–1.99 | 0.032 | 1.92 | 1.06–3.47 | |
| Diabetes | 0.914 | 1.03 | 0.58–1.84 | 0.708 | 1.24 | 0.40–3.79 | 0.499 | 1.28 | 0.63–2.58 | |
| Prior stroke | 0.513 | 1.23 | 0.67–2.25 | 0.361 | 0.53 | 0.14–2.06 | 0.855 | 0.93 | 0.45–1.96 | |
| Dyslipidemia | 0.224 | 1.36 | 0.83–2.22 | 0.487 | 1.37 | 0.57–3.29 | 0.492 | 0.80 | 0.42–1.52 | |
| Model 3 | ln(NT-proBNP) | <0.001 | 1.39 | 1.20–1.61 | <0.001 | 1.74 | 1.32–2.30 | 0.002 | 1.32 | 1.11–1.58 |
| sBP | 0.127 | 1.01 | 1.00–1.02 | 0.524 | 1.01 | 0.99–1.03 | 0.577 | 1.00 | 0.99–1.02 | |
| dBP | 0.753 | 1.00 | 0.99–1.02 | 0.337 | 0.99 | 0.96–1.01 | 0.826 | 1.00 | 0.98–1.02 | |
| Glucose | 0.006 | 1.13 | 1.03–1.23 | 0.103 | 1.11 | 0.98–1.26 | 0.119 | 1.08 | 0.98–1.18 | |
| Homocysteine | 0.042 | 1.02 | 1.00–1.03 | 0.028 | 1.02 | 1.00–1.04 | 0.305 | 1.01 | 0.99–1.02 | |
| Cholesterol | 0.512 | 0.83 | 0.47–1.45 | 0.615 | 0.77 | 0.29–2.10 | 0.277 | 1.49 | 0.73–3.04 | |
| Triglyceride | 0.855 | 1.03 | 0.76–1.39 | 0.583 | 0.83 | 0.43–1.61 | 0.901 | 0.98 | 0.67–1.43 | |
| LDL-C | 0.507 | 1.24 | 0.66–2.33 | 0.203 | 2.01 | 0.69–5.86 | 0.030 | 0.40 | 0.18–0.91 | |
| HDL-C | 0.220 | 1.67 | 0.74–3.78 | 0.340 | 2.05 | 0.47–8.92 | 0.371 | 0.63 | 0.22–1.75 | |
| Model 4 | ln(NT-proBNP) | <0.001 | 1.45 | 1.20–1.76 | 0.009 | 1.59 | 1.12–2.23 | 0.000 | 1.58 | 1.26–1.99 |
| Gender | 0.182 | 1.49 | 0.83–2.68 | 0.928 | 0.95 | 0.29–3.11 | 0.836 | 0.92 | 0.41–2.04 | |
| Age | 0.929 | 1.00 | 0.98–1.03 | 0.532 | 1.02 | 0.97–1.06 | 0.731 | 0.99 | 0.97–1.02 | |
| BMI | 0.266 | 1.05 | 0.97–1.14 | 0.775 | 1.02 | 0.88–1.19 | 0.067 | 1.11 | 0.99–1.23 | |
| ONT | 0.188 | 1.00 | 1.00–1.01 | 0.349 | 1.00 | 1.00–1.01 | 0.114 | 1.00 | 1.00–1.01 | |
| Dosage 0.9 mg/kg | 0.550 | 1.17 | 0.70–1.97 | 0.571 | 1.35 | 0.47–3.86 | 0.506 | 1.25 | 0.65–2.41 | |
| Bridging therapy | 0.252 | 1.51 | 0.75–3.05 | 0.252 | 0.41 | 0.09–1.90 | 0.005 | 3.05 | 1.39–6.67 | |
| NIHSS | <0.001 | 1.10 | 1.05–1.15 | 0.001 | 1.09 | 1.03–1.15 | 0.916 | 1.00 | 0.96–1.05 | |
| Smoking | 0.014 | 0.50 | 0.29–0.87 | 0.096 | 2.59 | 0.84–7.97 | 0.644 | 1.18 | 0.58–2.39 | |
| Drinking | 0.209 | 1.41 | 0.82–2.42 | 0.939 | 1.04 | 0.36–3.04 | 0.002 | 3.18 | 1.56–6.51 | |
| AF | 0.028 | 0.41 | 0.18–0.91 | 0.124 | 2.49 | 0.78–7.93 | 0.922 | 1.05 | 0.42–2.59 | |
| CHD | 0.351 | 0.76 | 0.42–1.36 | 0.757 | 1.19 | 0.40–3.49 | 0.017 | 0.40 | 0.19–0.85 | |
| Hypertension | 0.444 | 1.22 | 0.73–2.02 | 0.963 | 0.97 | 0.31–3.02 | 0.031 | 2.08 | 1.07–4.05 | |
| Diabetes | 0.768 | 1.11 | 0.56–2.20 | 0.611 | 0.67 | 0.14–3.16 | 0.401 | 1.44 | 0.61–3.38 | |
| Prior Stroke | 0.959 | 0.98 | 0.51–1.90 | 0.400 | 0.53 | 0.12–2.31 | 0.879 | 1.06 | 0.49–2.31 | |
| Dyslipidemia | 0.525 | 1.22 | 0.66–2.28 | 0.480 | 1.52 | 0.47–4.87 | 0.230 | 0.61 | 0.28–1.36 | |
| sBP | 0.344 | 1.01 | 0.99–1.02 | 0.729 | 1.00 | 0.98–1.03 | 0.773 | 1.00 | 0.99–1.02 | |
| dBP | 0.693 | 1.00 | 0.99–1.02 | 0.255 | 0.98 | 0.95–1.01 | 0.999 | 1.00 | 0.98–1.02 | |
| Glucose | 0.041 | 1.11 | 1.00–1.22 | 0.130 | 1.13 | 0.96–1.34 | 0.206 | 1.08 | 0.96–1.21 | |
| Homocysteine | 0.101 | 1.01 | 1.00–1.03 | 0.142 | 1.02 | 0.99–1.04 | 0.362 | 1.01 | 0.99–1.03 | |
| Cholesterol | 0.949 | 0.98 | 0.54–1.77 | 0.732 | 1.24 | 0.37–4.15 | 0.123 | 1.86 | 0.85–4.09 | |
| Triglyceride | 0.856 | 0.97 | 0.70–1.35 | 0.330 | 0.68 | 0.31–1.48 | 0.723 | 0.92 | 0.59–1.44 | |
| LDL-C | 0.968 | 1.01 | 0.51–2.00 | 0.591 | 1.42 | 0.39–5.16 | 0.006 | 0.28 | 0.11–0.70 | |
| HDL-C | 0.253 | 1.71 | 0.68–4.26 | 0.868 | 0.86 | 0.16–4.77 | 0.336 | 0.57 | 0.18–1.80 | |
Model 1 was adjusted for gender, age, BMI, ONT, dosage of rt-PA, bridging therapy, and NIHSS; Model 2 was adjusted for drinking, smoking, prior stroke, AF, CHD, hypertension, diabetes mellitus, prior stroke, and dyslipidemia; Model 3 was adjusted for sBP, dBP, baseline glucose, homocysteine, cholesterol, triglyceride, LDL-C, and HDL-C; Model 4 was adjusted for Model 1 + Model 2 + Model 3.
OR, Odds ratio; 95% CI, 95% confidence interval; BMI, Body mass index; ONT, Onset to needle time; NIHSS, The National Institutes of Health Stroke Scale; AF, Atrial fibrillation; CHD, Coronary heart disease; sBP, Systolic blood pressure; dBP, Diastolic blood pressure; LDL-C, Low density lipoprotein cholesterin; HDL-C, High density lipoprotein cholesterin; NT-proBNP, N-terminal of the prohormone brain natriuretic peptide.