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. 2021 Dec 2;14:5373–5383. doi: 10.2147/OTT.S342613

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© 2021 Wang and Liu.

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Construction of lncRNA-miRNA-mRNA regulatory axis. (A) A PPI network revealed TLR4 as the hub gene among prognostic gene signature. (B) The result of miRDB, TargetScan, and StarBase identified four miRNAs (hsa-miR-448, hsa-miR-1306-5p, hsa-miR-3924, and hsa-miR-21-5p) as the potential miRNA targets of TLR4. (C and D) The expression of miR-1306-5p and miR-21-5p in STAD tissues versus gastric tissues. (E) The result of StarBase and lncBase suggested SNHG1 as the lncRNA target of miR-21-5p. (F) The expression of SNHG1 in STAD tissues versus gastric tissues. (G and H) Prognosis revealed that STAD patients with high SNHG1 expression with a better overall survival and relapse-free survival. **P < 0.01, ****P < 0.0001.