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. 2021 Nov 30;9(4):E1114–E1119. doi: 10.9778/cmajo.20210023

Table 2:

Sequences, key acquisition parameters, sequence timing and protocol timing of magnetic resonance imaging of the brain*

MRI sequence† Parameters Scan time, min:s
3-dimensional magnetization-prepared rapid gradient-echo (MPRAGE)

  • TR/TE/TI = 2500/4.7/1100 ms; θ = 7°; FOV = 256 × 256 × 192 mm; 1-mm isotropic voxels

 3:45
3-dimensional T2-weighted fluid-attenuated inversion recovery (FLAIR)

  • TR/TE/TI = 5000/388/1800 ms; FOV = 256 × 256 × 192 mm; 1-mm isotropic voxels

 5:57
3-dimensional pseudocontinuous arterial spin labelling (pCASL)

  • Label duration = 1500 ms; postlabel delay = 1800 ms

  • 3-dimensional echo-planar turbo gradient spin echo readout

  • TR/TEeff = 4100/37 ms; FOV = 240 × 240 × 120 mm

  • 2.5-mm isotropic voxels; 10% oversampling

  • Turbo factor = 14; background suppression

 4:27
3-dimensional T2-weighted sampling perfection with application-optimized contrasts using different θ evolution (SPACE)

  • TR/TEeff = 3200/408 ms; FOV = 240 × 240 × 176 mm; 0.9-mm isotropic voxels

 3:42
2-dimensional multislice susceptibility-weighted imaging (SWI)

  • TR/TE = 28/20 ms; FOV = 240 × 240 × 156 mm

  • Acceleration factor = 2; 23.1% oversampling

  • 0.625-mm × 0.625-mm × 3.0-mm voxels

 4:02
2-dimensional multislice blood-oxygenation-level–dependent (BOLD) resting state functional MRI

  • 2-dimensional echo-planar imaging; TR/TE = 2130/30 ms; θ = 70°

  • FOV = 224 × 224 × 140 mm; 3.5-mm isotropic voxels

  • 250 time points

 9:00
2-dimensional multislice 3-shell diffusion-weighted imaging (DWI)

  • TR/TE = 4300/62 ms; FOV = 240 × 240 mm; 60 slices; 2.5-mm isotropic voxels

  • b = 700, 1400, 2100 s/mm2

  • 30 gradient directions; 4 b = 0 values; 1 average per shell

 8:34
Contrast agent administration –
Dynamic susceptibility contrast (DSC) MRI

  • 2-dimensional echo-planar imaging; TR/TE = 1250/30 ms; θ = 7°; FOV = 220 × 220 × 80 mm

  • 1.74-mm × 1.74-mm × 4.0-mm voxels; 140 time points

 3:07
Scanning paused

  • Delay until 10 min after contrast administration to permit gadolinium-enhanced T1-weighted acquisition

 6:53
3-dimensional MPRAGE 10 min after injection

  • As above

 3:45
Overall – 53:12

Note: θ = flip angle, FOV = field of view, MRI = magnetic resonance imaging, TE = echo time, TEeff = effective echo time, TI = inversion time, TR = repetition time.

*

Conducted with the standard head coil.

†

All sequences are part of the Siemens Healthineers Magnetom Prisma 3 T MRI system with the exception of the pCASL implementation.11