Figure 2.

Centrosomes and asymmetric stem cell division. During asymmetric division of GSCs, the mother centrosome is connected to the hub via adherens junctions in conjunction with Apc2, Bazooka, and Klp10A. In response to signals from the hub, GSC inherits the mother centrosome and retains a stem cell identity, while the sibling cell inherits the daughter centrosome and undergoes differentiation. In contrast, during asymmetric division in neural stem cells, the neuroblast inherits the daughter centrosome, while the ganglion mother cell inherits the mother centrosome. This may involve inhibition of mother centrosome activity by PLP and CEP135, which block Plk4 recruitment.