TABLE 2.
Aβ–PrPC interaction sites.
| Binding site of PrPC | Aβ species | Model | Cellular functions | References |
| 95–110 NA 96–104 NA N-terminus 91–231 | AβOs (∼500 kDa) Brain-derived Aβ AβOs (dimers) Aβ protofibrils AβOs (300 and 158 kDa) AβOs (HMW assemblies) AβOs (EC50 ∼30 nM) | PrPC-expressing COS-7 cells Prnp–/– and C57Bl6 slices Prnp–/– and APPswe/PSen1ΔE9 slices Aβ-containing AD brain Prnp–/– and C57Bl6 slices Synthetic and Aβ-containing AD brain Tg2576 mice and Aβ-containing AD brains Prnp–/– and C57BL/6J slices | Promotes LTP impairment, cell death, and cognitive impaired | Laurén et al., 2009; Gimbel et al., 2010; Barry et al., 2011; Nicoll et al., 2013; Dohler et al., 2014; Kostylev et al., 2015; Corbett et al., 2020 |
PrPC, cellular prion protein; AβOs, oligomers of Aβ peptide; LTP, long-term potentiation; Swe, Swedish mutation; PSen1, Presenilin-1, HMW, high-molecular-weight assemblies; AD, Alzheimer’s disease.