Fig. 1.

Best percentage change in the target lesion tumor burden from baseline in patients with a CT assessment

Waterfall plot for the maximum percentage reduction in the target lesion tumor burden until disease progression (study-off) according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 progression. A positive change in the tumor burden indicates tumor growth; a negative change in the tumor burden indicates a tumor reduction. The horizontal dotted lines denote a 30% decrease and 20% increase, indicating an objective response and progressive disease, respectively, as per RECIST version 1.1. The tumor type and presence or absence of adverse events (AEs) are annotated for each patient. 0.1 mg/ml (n=18), blue bar; 1.0 mg/ml (n=17), orange bar.