Table 2. The association between the study outcomes and variables in logistic regression analyses.

	Crude HR	95% CI	P	Adjusted HR	95% CI	P
*Age as a continuous variable and age ≥ 85 vs. < 85 years were adjusted separately. HR: hazard ratio; BP: blood pressure.
All-cause mortality
Age*, yrs	1.033	1.006−1.060	0.016	1.009	0.979−1.040	0.566
Age ≥ 85 vs. < 85 yrs*	2.332	1.302−4.177	0.004	1.958	0.937−4.090	0.074
Male gender	1.652	0.865−3.156	0.128	0.528	0.273−1.021	0.058
Body mass index, kg/m2	0.918	0.850−0.990	0.027	0.946	0.867−1.031	0.208
Current/past smoker	0.925	0.558−1.532	0.762
Alcohol intake	0.863	0.580−1.283	0.465
History of hypertension	0.675	0.388−1.175	0.164
History of diabetes mellitus	0.777	0.440−1.370	0.383
Chronic kidney disease	1.055	0.756−1.474	0.752
History of carotid artery stenosis	0.049	0.000−1058	0.553
History of ischemic stroke	1.361	0.681−2.717	0.383
History of chronic heart failure	1.035	0.799−1.339	0.797
Atrial fibrillation	2.435	1.274−4.654	0.007	1.535	0.710−3.320	0.276
Presented with acute ischemic limb	4.133	2.257−7.567	< 0.001	1.813	0.827−3.976	0.137
Rutherford classification	2.073	1.330−3.233	0.001	2.008	1.163−3.467	0.012
Systolic BP at baseline, mmHg	0.995	0.986−1.005	0.325
Diastolic BP at baseline, mmHg	1.013	0.992−1.033	0.226
Heart rate at baseline, beats/min	1.026	1.011−1.042	0.001	1.015	0.996−1.034	0.125
Total cholesterol, mg/dL	1.001	0.995−1.007	0.765
High-density lipoprotein cholesterol, mg/dL	0.995	0.961−1.031	0.796
Low-density lipoprotein cholesterol, mg/dL	0.994	0.978−1.010	0.454
Triglyceride, mg/dL	0.997	0.993−1.001	0.095
Fasting glucose, mg/dL	0.999	0.997−1.002	0.708
Glycosylated hemoglobin, %	1.106	0.917−1.333	0.291
Creatinine, mg/dL	1.018	0.943−1.099	0.640
Creatinine clearance	0.989	0.977−1.002	0.103
Estimated glomerular filtration rate, mL/min per 1.732 m2	0.998	0.989−1.006	0.585
Alanine transaminase, IU/L	1.020	1.012−1.028	< 0.001	1.012	1.001−1.024	0.029
Uric acid, mg/dL	1.017	0.888−1.164	0.810
White blood cell count, 103/μL	1.000	1.000−1.000	< 0.001
Neutrophil ratio, %	1.052	1.026−1.079	< 0.001
Lymphocyte ratio, %	0.917	0.884−0.952	< 0.001
Neutrophil-to-lymphocyte ratio	1.030	1.016−1.044	< 0.001	1.031	1.011−1.052	0.002
Cardiac-related mortality
Age*, yrs	1.031	0.994−1.069	0.100	1.012	0.973−1.052	0.559
Age ≥ 85 vs. < 85 yrs*	2.101	0.913−4.837	0.081	1.628	0.607−4.366	0.333
Male gender	0.987	0.340−2.863	0.980	0.588	0.250−1.385	0.224
Body mass index, kg/m2	0.917	0.826−1.016	0.098	0.931	0.830−1.044	0.222
Current/past smoker	1.027	0.525−2.009	0.938
Alcohol intake	1.056	0.638−1.751	0.831
History of hypertension	0.694	0.319−1.511	0.358
History of diabetes mellitus	1.246	0.524−2.963	0.619
Chronic kidney disease	1.068	0.670−1.701	0.784
History of carotid artery stenosis	0.049	0.000−52618	0.670
History of ischemic stroke	0.737	0.221−2.455	0.619
History of chronic heart failure	1.237	0.914−1.674	0.169
Atrial fibrillation	2.436	0.977−6.072	0.056
Presented with acute ischemic limb	3.769	1.579−8.998	0.003	1.815	0.646−5.101	0.258
Rutherford classification	1.346	0.778−2.327	0.288	1.294	0.684−2.448	0.429
Systolic BP at baseline, mmHg	0.999	0.986−1.013	0.928
Diastolic BP at baseline, mmHg	1.021	0.993−1.049	0.151
Heart rate at baseline, beats/min	1.039	1.018−1.061	< 0.001	1.029	1.006−1.054	0.014
Total cholesterol, mg/dL	1.002	0.994−1.010	0.619
High-density lipoprotein cholesterol, mg/dL	0.989	0.940−1.040	0.664
Low-density lipoprotein cholesterol, mg/dL	1.001	0.982−1.021	0.915
Triglyceride, mg/dL	0.997	0.993−1.002	0.239
Fasting glucose, mg/dL	1.000	0.996−1.004	0.835
Glycosylated hemoglobin, %	1.108	0.867−1.416	0.414
Creatinine, mg/dL	1.007	0.902−1.125	0.897
Creatinine clearance	0.999	0.984−1.014	0.873
Estimated glomerular filtration rate, mL/min per 1.732 m2	1.004	0.994−1.015	0.448
Alanine transaminase, IU/L	1.019	1.007−1.031	0.002	1.010	0.996−1.025	0.159
Uric acid, mg/dL	1.040	0.860−1.257	0.688
White blood cell count, 103/μL	1.000	1.000−1.000	0.018
Neutrophil ratio, %	1.057	1.019−1.096	0.003
Lymphocyte ratio, %	0.902	0.854−0.953	< 0.001
Neutrophil-to-lymphocyte ratio	1.027	1.006−1.049	0.011	1.028	0.999−1.058	0.058
Major adverse limb events
Age*, yrs	0.979	0.952−1.007	0.146	0.966	0.931−1.002	0.063
Age ≥ 85 vs. < 85 yrs*	0.507	0.179−1.439	0.202	0.141	0.026−0.772	0.024
Male gender	1.145	0.582−2.253	0.696	1.487	0.720−3.072	0.284
Body mass index, kg/m2	0.941	0.864−1.025	0.160	0.897	0.806−0.998	0.046
Current/past smoker	1.009	0.553−1.841	0.977
Alcohol intake	0.854	0.522−1.397	0.528
History of hypertension	0.842	0.422−1.682	0.627
History of diabetes mellitus	1.332	0.622−2.854	0.461
Chronic kidney disease	1.499	1.028−2.184	0.035	1.588	1.023−2.465	0.039
History of carotid artery stenosis	2.110	0.289−15.434	0.462
History of ischemic stroke	1.151	0.476−2.779	0.755
History of chronic heart failure	1.211	0.922−1.591	0.169
Atrial fibrillation	1.280	0.495−3.307	0.610
Presented with acute ischemic limb	0.976	0.344−2.770	0.963	0.745	0.201−2.763	0.660
Rutherford classification	4.227	2.339−7.636	< 0.001	7.642	3.438−16.984	< 0.001
Systolic BP at baseline, mmHg	0.991	0.980−1.002	0.105
Diastolic BP at baseline, mmHg	0.984	0.960−1.008	0.196
Heart rate at baseline, beats/min	0.999	0.980−1.018	0.926
Total cholesterol, mg/dL	0.988	0.979−0.997	0.010	0.989	0.979−0.999	0.043
High-density lipoprotein cholesterol, mg/dL	1.006	0.980−1.034	0.639
Low-density lipoprotein cholesterol, mg/dL	0.987	0.974−1.001	0.071
Triglyceride, mg/dL	1.000	0.998−1.003	0.844
Fasting glucose, mg/dL	1.003	1.000−1.006	0.037	1.004	1.001−1.008	0.018
Glycosylated hemoglobin, %	1.171	0.978−1.403	0.086
Creatinine, mg/dL	1.044	0.957−1.138	0.337
Creatinine clearance	0.995	0.981−1.009	0.496
Estimated glomerular filtration rate, mL/min per 1.732 m2	0.990	0.978−1.002	0.089
Alanine transaminase, IU/L	1.002	0.987−1.017	0.816
Uric acid, mg/dL	0.906	0.765−1.073	0.251
White blood cell count, 103/μL	1.000	1.000−1.000	0.006
Neutrophil ratio, %	1.047	1.017−1.079	0.002
Lymphocyte ratio, %	0.933	0.894−0.974	0.001
Neutrophil-to-lymphocyte ratio	1.016	0.992−1.040	0.190	0.972	0.933−1.012	0.172
Major adverse cardiovascular events
Age*, yrs	1.016	0.986−1.046	0.300	0.992	0.959−1.026	0.992
Age ≥ 85 vs. < 85 yrs*	2.138	1.074−4.256	0.031	1.350	0.604−3.015	0.465
Male gender	1.012	0.422−2.426	0.978	0.735	0.371−1.456	0.377
Body mass index, kg/m2	0.923	0.849−1.004	0.062	0.939	0.858−1.029	0.178
Current/past smoker	1.523	0.945−2.454	0.084
Alcohol intake	1.111	0.731−1.690	0.621
History of hypertension	0.753	0.391−1.452	0.398
History of diabetes mellitus	1.318	0.638−2.723	0.456
Chronic kidney disease	0.937	0.623−1.411	0.756
History of carotid artery stenosis	0.049	0.000−7539	0.620
History of ischemic stroke	1.044	0.436−2.503	0.923
History of chronic heart failure	1.191	0.913−1.553	0.198
Atrial fibrillation	2.479	1.169−5.257	0.018	1.597	0.678−3.764	0.284
Presented with acute ischemic limb	2.592	1.222−5.497	0.013	2.088	0.905−4.818	0.085
Rutherford classification	1.257	0.806−1.960	0.314	1.181	0.723−1.928	0.506
Systolic BP at baseline, mmHg	0.998	0.988−1.009	0.715
Diastolic BP at baseline, mmHg	1.008	0.985−1.031	0.506
Heart rate at baseline, beats/min	1.025	1.008−1.042	0.004	1.025	1.005−1.045	0.015
Total cholesterol, mg/dL	1.003	0.997−1.010	0.342
High-density lipoprotein cholesterol, mg/dL	0.984	0.950−1.020	0.385
Low-density lipoprotein cholesterol, mg/dL	1.004	0.991−1.017	0.575
Triglyceride, mg/dL	0.999	0.995−1.002	0.434
Fasting glucose, mg/dL	0.998	0.995−1.002	0.401
Glycosylated hemoglobin, %	1.185	0.975−1.440	0.088
Creatinine, mg/dL	0.973	0.877−1.080	0.610
Creatinine clearance	1.004	0.993−1.016	0.463
Estimated glomerular filtration rate, mL/min per 1.732/m2	1.006	0.997	1.014	0.174
Alanine transaminase, IU/L	1.009	0.997−1.020	0.143
Uric acid, mg/dL	1.047	0.905−1.213	0.536
White blood cell count, 103/μL	1.000	1.000−1.000	0.240
Neutrophil ratio, %	1.026	0.999−1.054	0.062
Lymphocyte ratio, %	0.955	0.920−0.992	0.017
Neutrophil-to-lymphocyte ratio	1.016	0.993−1.039	0.176	1.010	0.978−1.043	0.533
In-hospital mortality
Age*, yrs	1.056	1.006−1.108	0.027	0.995	0.934−1.061	0.885
Age ≥ 85 vs. < 85 yrs*	3.694	1.425−9.576	0.007	2.386	0.442−12.881	0.312
Male gender	1.147	0.330−3.990	0.830	0.766	0.211−2.776	0.685
Body mass index, kg/m2	0.795	0.681−0.928	0.004	0.858	0.711−1.036	0.112
Current/past smoker	0.828	0.323−2.121	0.694
Alcohol intake	0.896	0.457−1.757	0.749
History of hypertension	0.761	0.290−1.999	0.579
History of diabetes mellitus	0.685	0.261−1.798	0.442
Chronic kidney disease	0.931	0.509−1.700	0.815
History of carotid artery stenosis	0.049	0.000−> 9999	0.742
History of ischemic stroke	1.114	0.320−3.876	0.865
History of chronic heart failure	0.752	0.394−1.438	0.389
Atrial fibrillation	2.120	0.691−6.503	0.189
Presented with acute ischemic limb	9.256	3.564−24.043	< 0.001	3.874	1.070−14.024	0.039
Rutherford classification	4.564	1.934−10.774	0.001	6.867	2.189−21.541	0.001
Systolic BP at baseline, mmHg	0.981	0.965−0.998	0.031	0.989	0.969−1.009	0.272
Diastolic BP at baseline, mmHg	1.018	0.985−1.052	0.292
Heart rate at baseline, beats/min	1.043	1.020−1.067	0.000	1.025	0.984−1.067	0.243
Total cholesterol, mg/dL	0.994	0.982−1.005	0.291
High-density lipoprotein cholesterol, mg/dL	0.956	0.880−1.038	0.280
Low-density lipoprotein cholesterol, mg/dL	0.993	0.967−1.020	0.613
Triglyceride, mg/dL	0.998	0.993−1.004	0.537
Fasting glucose, mg/dL	1.000	0.996−1.005	0.884
Glycosylated hemoglobin, %	1.058	0.757−1.479	0.741
Creatinine, mg/dL	1.001	0.870−1.152	0.988
Creatinine clearance	0.976	0.949−1.004	0.093
Estimated glomerular filtration rate, mL/min per 1.732 m2	0.999	0.985−1.014	0.931
Alanine transaminase, IU/L	1.019	1.008−1.030	0.001	1.002	0.984−1.202	0.843
Uric acid, mg/dL	1.124	0.914−1.381	0.268
White blood cell count, 103/μL	1.000	1.000−1.000	0.001
Neutrophil ratio, %	1.115	1.052−1.182	< 0.001
Lymphocyte ratio, %	0.869	0.802−0.942	0.001
Neutrophil-to-lymphocyte ratio	1.038	1.018−1.059	< 0.001	1.052	1.021−1.084	0.001