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. 2021 Dec 6;53(12):1636–1648. doi: 10.1038/s41588-021-00973-1

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — Correlation matrix for genetic correlation estimates obtained from bivariate LD score regression. Colors correspond to genetic correlation estimates. Strongest clusters appear between neurodegenerative diseases and within the psychiatric traits. ALS = amyotrophic lateral sclerosis, FTD = frontotemporal dementia, PSP progressive supranuclear palsy, PD = Parkinson’s disease, CBD = corticobasal degeneration, AD = (clinically diagnosed) Alzheimer’s disease, MS = multiple sclerosis, IS = ischemic stroke (any), ICH = intracerebral hemorrhage, IA = intracranial aneurysm (any), AN = anorexia nervosa, OCD = obsessive compulsive disorder, Anxiety = anxiety disorder (score), PTSD = post-traumatic stress disorder, MDD = major depressive disorder, BIP = bipolar disorder, SCZ = schizophrenia, TS = Tourette’s syndrome, ASD = autism spectrum disorder, ADHD = attention-deficit hyperactivity disorder.

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