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. 2021 Dec 6;53(12):1636–1648. doi: 10.1038/s41588-021-00973-1

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — Tissue (a) and cell-type (b) enrichment for all included brain diseases obtained from two-sided MAGMA linear regression. Only brain diseases with exome-wide significant gene-based MAGMA associations (P < 2.7 × 10⁻⁶) were suitable for tissue and cell-type enrichment analyses. The color represents enrichment coefficient and size indicates two-sided -log₁₀(P-value) of enrichment obtained by the linear regression model in the MAGMA gene-property analysis. Due to the large number of significant genes in the gene-based MAGMA analyses for schizophrenia, bipolar disorder and multiple sclerosis the enrichment P-values were truncated at P < 1.0 × 10⁻⁵. ALS = amyotrophic lateral sclerosis, PD = Parkinson’s disease, AD = Alzheimer’s disease, ADHD = attention-deficit hyperactivity disorder, ASD = autism spectrum disorder, TS = Tourette’s syndrome, SCZ = schizophrenia, BIP = bipolar disorder, MDD = major depressive disorder, PTSD = post-traumatic stress disorder, Anxiety = anxiety disorder (score), AN = anorexia nervosa, IA intracranial aneurysm (any), IS = ischemic stroke, MS = multiple sclerosis, Cx = cortex, OPC = oligodendrocyte progenitor cells.

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