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. 2021 Dec 6;53(12):1636–1648. doi: 10.1038/s41588-021-00973-1

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Cox proportional HRs for genome-wide significant SNPs (brown, n = 15), PRSs (red, n = 2) and rare variant burden in ALS-risk genes (pink, n = 7) on survival (months) tested in 6,095 patients with ALS. Estimated HRs are displayed with error bars corresponding to 95% CIs. Higher HRs correspond to shorter survival times. b, Effect estimates from a linear regression model of age at onset (years) in 6,095 patients with ALS. Lower effect estimates correspond to a younger age at onset. Effect estimates from linear regression are displayed with error bars corresponding to 95% CIs. The risk-increasing allele for ALS corresponds to the effect allele for both survival and age-at-onset analyses.

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