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. 2021 Dec 6;53(12):1636–1648. doi: 10.1038/s41588-021-00973-1

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Genetic correlation analysis. Genetic correlation was estimated with LDSC between each pair of neurodegenerative diseases (ALS, AD, CBD, PD, PSP and FTD). Correlations marked with an asterisk reached nominal statistical significance (P_ALS,AD = 0.01, P_ALS,PD = 0.01, P_ALS,PSP = 0.0001, P_PSP,PD = 0.002). b, SNP associations of ALS lead SNPs or LD proxies in neurodegenerative diseases. The association with ALS is shown at the top. Effective sample size is shown on the left. Posterior probabilities of the same causal SNP affecting two diseases were estimated through colocalization analysis and are highlighted as connections.

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